dimethisterone

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Names

[ CAS No. ]:
79-64-1

[ Name ]:
dimethisterone

[Synonym ]:
Secrosteron
Dimethisterone
Dimethisteron
Dimethisterone anhydrous
6a,21-dimethylethisterone
Lutogan

Chemical & Physical Properties

[ Density]:
1.11g/cm3

[ Boiling Point ]:
479ºC at 760 mmHg

[ Melting Point ]:
102°

[ Molecular Formula ]:
C₂₃H₃₂O₂

[ Molecular Weight ]:
340.49900

[ Flash Point ]:
203.5ºC

[ Exact Mass ]:
340.24000

[ PSA ]:
37.30000

[ LogP ]:
4.51870

[ Index of Refraction ]:
1.566

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8510000

CHEMICAL NAME :: Androst-4-en-3-one, 17-beta-hydroxy-6-alpha-methyl-17-(1-propynyl)-

CAS REGISTRY NUMBER :: 79-64-1

LAST UPDATED :: 199510

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C23-H32-O2

MOLECULAR WEIGHT :: 340.55

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 E1 FQ F1UU2 L1 -A&L -B&AEF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 17-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 175 mg/kg

SEX/DURATION :: female 15-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 38,128,1961

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 28 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 5,57,1972 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 21,377,1979

Related Compounds

Dimethisterone and ethinyl estradiol
N,N-Dimethyl-3-[(1-methylheptyl)amino]benzenemethanamine
4-[8-(3,4-Dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-3-methylbenzamide
Methyl 4-oxo-2-propan-2-ylcyclohexane-1-carboxylate
6,7-Dimethoxy-4-(trifluoromethyl)-N-(triphenylphosphoranylidene)-2-quinolinamine
N-(1-cyanocyclohexyl)-2-(4-hydroxypiperidin-1-yl)acetamide
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-N,N-dimethylbenzamide
1,3-dimethyl-N-(pentan-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-amine
3,6-dichloro-N-[3-(2-sulfanyl-1H-imidazol-1-yl)phenyl]pyridine-2-carboxamide
3-[8-(3,4-dimethoxyanilino)imidazo[1,2-a]pyrazin-6-yl]-N-methylbenzamide
N-(1-ethyl-2-oxoindolin-5-yl)furan-2-carboxamide

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