Daltroban

Suppliers

Names

[ Name ]:
Daltroban

[Synonym ]:
4-[2-(4-Chlorobenzene-sulfonamido)ethyl]benzeneacetic acid
[4-[2-(4-chlorobenzenesulfonamido)ethyl]phenyl]acetic acid
2-[4-[2-(4-chlorophenylsulphonylamino)-ethyl]-phenyl]-acetic acid
4-[2-[(4-CHLOROPHENYLSULFONYL)AMINO]ETHYL]BENZENEACETIC ACID
DatelliptiumChloride
2-[4-[2-(4-chlorophenyl)sulfonylaminoethyl]phenyl]acetic acid
4-[2-(4-chlorobenzenesulphonamido)-ethyl]-phenylacetic acid
4-((((4-chlorophenyl)sulfonyl)amino)ethyl)benzene acetic acid
MFCD00868295

Chemical & Physical Properties

[ Density]:
1.378g/cm3

[ Boiling Point ]:
555.3ºC at 760 mmHg

[ Melting Point ]:
132.5-137.4 °C(lit.)

[ Molecular Formula ]:
C₁₆H₁₆ClNO₄S

[ Molecular Weight ]:
353.82100

[ Flash Point ]:
289.6ºC

[ Exact Mass ]:
353.04900

[ PSA ]:
91.85000

[ LogP ]:
3.95980

[ Appearance of Characters ]:
white

[ Vapour Pressure ]:
3.63E-13mmHg at 25°C

[ Index of Refraction ]:
1.609

[ Water Solubility ]:
DMSO: 22 mg/mL, soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Cyclooxygenase-2 inhibition and thromboxane A(2) receptor antagonism attenuate hypoxic pulmonary vasoconstriction in a porcine model.

Acta Physiol. (Oxf.) 205(4) , 507-19, (2012)

Hypoxic pulmonary vasoconstriction (HPV) causes pulmonary hypertension that may lead to right heart failure. We hypothesized that the COX-2 inhibitor nimesulide and the thromboxane A(2) receptor antag...

Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets.

Thromb. Haemost. 87(1) , 114-21, (2002)

Arachidonic acid (AA) is a potent inducer of platelet aggregation in vitro; this activity is due to its conversion to biologically active metabolites, prostaglandin (PG) endoperoxides and thromboxane ...

Increase by anaphylatoxin C5a of glucose output in perfused rat liver via prostanoids derived from nonparenchymal cells: direct action of prostaglandins and indirect action of thromboxane A(2) on hepatocytes.

Hepatology 30 , 454-461, (1999)

In the perfused rat liver the anaphylatoxin C5a enhanced glucose output, reduced flow, and elevated prostanoid overflow. Because hepatocytes (HCs) do not express C5a receptors, the metabolic C5a actio...

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