Triphenylphosphine oxide

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Names

[ CAS No. ]:
791-28-6

[ Name ]:
Triphenylphosphine oxide

[Synonym ]:
Triphenylphosphine oxid
Triphenylphosphinoxid
Triphenylphosphan-oxid
Triphenylphosphine oxide
triphenyl-phosphineoxid
EINECS 212-338-8
Phosphorane, triphenyl-, oxide
triphenylphosphorusoxide
Ph3P=O
Triphenylphosphoniumolate
TPO
phosphorus(1+), hydroxytriphenyl-, inner salt
MFCD00002080
Triphenylphosphanoxid
AURORA KA-1603
Triphenylphosphineoxide
TPPO
(C6H5)3P=O
Triphenylphosphanoxide
Triphenyl Phosphine Oxide

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
462.9±18.0 °C at 760 mmHg

[ Melting Point ]:
150-157 °C(lit.)

[ Molecular Formula ]:
C18H15OP

[ Molecular Weight ]:
278.285

[ Flash Point ]:
233.8±21.2 °C

[ Exact Mass ]:
278.086060

[ PSA ]:
26.88000

[ LogP ]:
2.87

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.619

[ Storage condition ]:
Store at RT.

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ1676000
CHEMICAL NAME :
Phosphine oxide, triphenyl-
CAS REGISTRY NUMBER :
791-28-6
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C18-H15-O-P
MOLECULAR WEIGHT :
278.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(4),22,1990
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - aggression Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570648 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9397 No. of Facilities: 96 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 2100 (estimated) No. of Female Employees: 17 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335-H412

[ Precautionary Statements ]:
P261-P273-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R52/53

[ Safety Phrases ]:
S26-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
SZ1676000

[ Packaging Group ]:
I; II; III

[ Hazard Class ]:
6.1

[ HS Code ]:
29310095

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • dichlorotriphenylphosphorane
  • Bromobenzene
  • Diphenylphosphine oxide
  • 5-Bromo-1H-pyrazolo[3,4-b]pyridine
  • [3-(4-Morpholinylcarbonyl)phenyl]boronic acid
  • Ethyl diphenylphosphinite
  • 2-trimethylsilylphenyl triflate
  • 2,4-dimethoxybenzaldehyde
  • (Z)-3-(4-bromophenyl)-3-iodoprop-2-en-1-ol
  • 3-(5-bromo-2-methoxyphenylsulfonyloxy)-5-methylphenol

DownStream

  • N-(triphenyl-λ5-phosphanylidene)benzenesulfonamide
  • Diphenylphosphine oxide
  • Triphenylphosphine
  • Diphenylphosphine
  • oxo(phenyl)phosphane
  • benzene
  • Sulfinyldibenzene
  • 2-methyldibenzo[b,d]thiophene 5-oxide
  • diphenyl(p-tolyl)phosphine oxide

Customs

[ HS Code ]: 29310095

Articles

Toward prediction of alkane/water partition coefficients.

J. Med. Chem. 51 , 3720-30, (2008)

Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the pa...

Mechanism of lipid peroxidation in cancer cells in response to gamma-linolenic acid (GLA) analyzed by GC-MS(I): Conjugated dienes with peroxyl (or hydroperoxyl) groups and cell-killing effects.

Anticancer Res. 13(1) , 193-9, (1993)

We have investigated the nature of lipid peroxidation occurring in association with cancer-killing produced by gamma-linolenic acid (GLA) and iron (Fe) in cultured human breast cancer cells (ZR-75-1: ...

Solubilization of triphenylamine, triphenylphosphine, triphenylphosphineoxide and triphenylmethanol in single and binary surfactant systems.

J. Colloid. Interface Sci. 364(1) , 163-9, (2011)

Solubilization and co-solubilization of triphenyls (TPs) viz., triphenylphosphine (TPP), triphenylphosphineoxide (TPPO), triphenylamine (TPA) and triphenylmethanol (TPM) were studied in various single...


More Articles

Related Compounds

  • triphenylphosphine oxide diiodine
  • Perfluorotriphenylphosphine oxide
  • triphenylphosphine oxide hydrochloride
  • tris(p-carboxylic)triphenylphosphine oxide
  • triphenylphosphine oxide-nitric acid complex
  • di-iodo-bis(triphenylphosphine oxide)-cobalt(II)