Sertraline hydrochloride
Suppliers
Names
[ CAS No. ]:
79559-97-0
[ Name ]:
Sertraline hydrochloride
[Synonym ]:
(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine hydrochloride
Zoloft
EINECS 200-659-6
(1S,4S)-4-(3,4-Dichlorphenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-aminhydrochlorid
Sertraline hydrochloride
(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride (1:1)
(+)-sertraline hydrochloride
CP-51974-1
(+)-cis-(1S,4S)-1-methylamino-4-(3,4-dichlorophenyl)tetralin hydrochloride
CP 51974-1
1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-, hydrochloride (1:1)
(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine hydrochloride
(1S,4S)-4-(3,4-dichlorophényl)-N-méthyl-1,2,3,4-tétrahydronaphtalén-1-amine chlorhydrate
Cp 51,974-1
(1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
MFCD00895772
(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride
1-naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-, hydrochloride
Lustral
Sertraline.HCl
(1S,4S)-4-(3,4-Dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride (1:1)
(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride
Sertraline (hydrochloride)
Chemical & Physical Properties
[ Boiling Point ]:
416.3ºC at 760 mmHg
[ Melting Point ]:
246-249°C
[ Molecular Formula ]:
C17H18Cl3N
[ Molecular Weight ]:
342.690
[ Flash Point ]:
205.6ºC
[ Exact Mass ]:
341.050476
[ PSA ]:
12.03000
[ LogP ]:
6.37250
[ Storage condition ]:
Desiccate at RT
[ Stability ]:
Store in Freezer
[ Water Solubility ]:
DMSO: ~26 mg/mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QJ0352070
- CHEMICAL NAME :
- 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, hydrochloride, (1S-cis)-
- CAS REGISTRY NUMBER :
- 79559-97-0
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C17-H17-Cl2-N.Cl-H
- MOLECULAR WEIGHT :
- 342.71
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 7 mg/kg/2W-I
- TOXIC EFFECTS :
- Behavioral - headache Musculoskeletal - changes in teeth and supporting structures Skin and Appendages - sweating
- REFERENCE :
- JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 54,432,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 7 mg/kg/7D-I
- TOXIC EFFECTS :
- Behavioral - excitement
- REFERENCE :
- JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 54,321,1993 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 56 mg/kg
- SEX/DURATION :
- female 5 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - breasts, lactation (prior to or during pregnancy)
- REFERENCE :
- AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 150,1269,1993
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311 + H331-H370
[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution
[ WGK Germany ]:
3
[ RTECS ]:
QJ0352070
[ HS Code ]:
2921300090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921499090
[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Drug Des. Devel. Ther. 9 , 3885-98, (2015)
Delivering drugs to intracerebral regions can be accomplished by improving the capacity of transport through blood-brain barrier. Using sertraline as model drug for brain targeting, the current study ...
BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...
Chemosphere 135 , 146-55, (2015)
Sertraline is one of the most commonly prescribed selective serotonin reuptake inhibitors and is frequently detected in the aquatic environment. However, knowledge regarding relationships among molecu...