Linifanib (ABT-869)

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Names

[ CAS No. ]:
796967-16-3

[ Name ]:
Linifanib (ABT-869)

[Synonym ]:
Linifanib
S1003_Selleck
Kinome_532
ABT 869
ABT-869

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
542.2±50.0 °C at 760 mmHg

[ Melting Point ]:
180-183ºC (dec.)

[ Molecular Formula ]:
C21H18FN5O

[ Molecular Weight ]:
375.399

[ Flash Point ]:
281.7±30.1 °C

[ Exact Mass ]:
375.149536

[ PSA ]:
95.83000

[ LogP ]:
4.34

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.766

[ Storage condition ]:
-20?C Freezer

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Iodo-1H-indazol-3-amine
  • N-(2-Fluoro-5-methylphenyl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea
  • 4-chloro-1H-indazol-3-amine
  • 3-Amino-4-fluorotoluene
  • 2-Fluoro-6-iodobenzonitrile
  • 4-AMinophenylboronic acid pinacol ester
  • N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate

DownStream

Related Compounds

  •
  • (Rac)-ABT-202 dihydrochloride
  • Veliparib (ABT-888)
  • Cethromycin
  • Venetoclax (ABT-199)
  • AscroliMus(ABT-281)
  • 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methyl-2-phenylpentanoic acid
  • 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-[4-(2-methylpropyl)phenyl]propanoic acid
  • 2-(2-bromophenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • 2-(3-bromo-4-fluorophenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid
  • 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-{4-[(trifluoromethyl)sulfanyl]phenyl}acetic acid
  • 2-(4-ethylphenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid
  • 2-(5-bromo-2-methoxyphenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetic acid
  • 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methyl-2-phenylbutanoic acid
  • 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)thiane-3-carboxylic acid
  • 4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methyloxane-4-carboxylic acid
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