Linifanib (ABT-869)

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Names

[ CAS No. ]:
796967-16-3

[ Name ]:
Linifanib (ABT-869)

[Synonym ]:
Linifanib
S1003_Selleck
Kinome_532
ABT 869
ABT-869

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
542.2±50.0 °C at 760 mmHg

[ Melting Point ]:
180-183ºC (dec.)

[ Molecular Formula ]:
C21H18FN5O

[ Molecular Weight ]:
375.399

[ Flash Point ]:
281.7±30.1 °C

[ Exact Mass ]:
375.149536

[ PSA ]:
95.83000

[ LogP ]:
4.34

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.766

[ Storage condition ]:
-20?C Freezer

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Iodo-1H-indazol-3-amine
  • N-(2-Fluoro-5-methylphenyl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea
  • 4-chloro-1H-indazol-3-amine
  • 3-Amino-4-fluorotoluene
  • 2-Fluoro-6-iodobenzonitrile
  • 4-AMinophenylboronic acid pinacol ester
  • N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea monohydrate

DownStream

Related Compounds

  •
  • (Rac)-ABT-202 dihydrochloride
  • Veliparib (ABT-888)
  • Cethromycin
  • Venetoclax (ABT-199)
  • AscroliMus(ABT-281)
  • 1,2-dimethyl-N-((2-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)methyl)-1H-imidazole-4-sulfonamide
  • 2-(4-(N-((2-methyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)methyl)sulfamoyl)phenoxy)acetamide
  • 3-phenyl-1-(1-(2-phenyl-2H-1,2,3-triazole-4-carbonyl)piperidin-4-yl)imidazolidine-2,4-dione
  • 1-(1-(4-methyl-2-(1H-pyrrol-1-yl)thiazole-5-carbonyl)piperidin-4-yl)-3-phenylimidazolidine-2,4-dione
  • 1-(1-(2-(1H-indol-1-yl)acetyl)piperidin-4-yl)-3-phenylimidazolidine-2,4-dione
  • 3-Phenyl-1-(1-(2-phenylthiazole-4-carbonyl)piperidin-4-yl)imidazolidine-2,4-dione
  • 1-(1-(4-Oxo-4-phenylbutanoyl)piperidin-4-yl)-3-phenylimidazolidine-2,4-dione
  • (E)-1-(1-(3-(furan-2-yl)acryloyl)piperidin-4-yl)-3-phenylimidazolidine-2,4-dione
  • 1-(1-(2-(1H-benzo[d]imidazol-1-yl)acetyl)piperidin-4-yl)-3-phenylimidazolidine-2,4-dione
  • 1-(1-(5-(Furan-2-yl)isoxazole-3-carbonyl)piperidin-4-yl)-3-phenylimidazolidine-2,4-dione
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