Neridronate

Suppliers

Names

[ CAS No. ]:
79778-41-9

[ Name ]:
Neridronate

[Synonym ]:
(6-Amino-1-hydroxy-1,1-hexanediyl)bis(phosphonic acid)
Neridronic
6-amino-1-hydroxyhexane-1,1-diphosphonic acid
NERIXIA
6-amino-1-hydroxy-1,1-hexylidenebisphosphonic acid
Phosphonic acid, (6-amino-1-hydroxyhexylidene)bis-
(6-amino-1-hydroxyhexylidene)bisphosphonate
6-AMINO-1-HYDROXYHEXYLIDENE BISPHOSPHONIC ACID
6-Amino-1-hydroxyhexylidene bisphosphonic acid,Neridronic acid,Nerixia
6-amino-1-hydroxyhexane-1,1-diphosphonate
(6-amino-1-hydroxy-1-phosphonohexyl)phosphonic acid
(6-Amino-1-hydroxyhexane-1,1-diyl)bis(phosphonic acid)
NERIDRONATE
Neridronic acid

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
600.1±65.0 °C at 760 mmHg

[ Melting Point ]:
245°

[ Molecular Formula ]:
C6H17NO7P2

[ Molecular Weight ]:
277.149

[ Flash Point ]:
316.7±34.3 °C

[ Exact Mass ]:
277.048035

[ PSA ]:
180.93000

[ LogP ]:
-3.36

[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C

[ Index of Refraction ]:
1.569

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 8 mg/mL, soluble

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-Aminocaproic acid
  • phosphorous acid
  • 6-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-hexanoic
  • 6-phthalimidohexanoic acid chloride

DownStream

Articles

Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment.

Eur. J. Pharm. Biopharm. 76(1) , 120-6, (2010)

Recognition of bone mineral by bisphosphonates is crucial to their targeting, efficacy, therapeutic and diagnostic applications, and pharmacokinetics. In a search for rapid and simple NMR approaches t...

Intramuscular neridronate in postmenopausal women with low bone mineral density.

Calcif. Tissue Int. 83(5) , 301-7, (2008)

Compliance to osteoporosis treatment with oral bisphosphonates is very poor. Intermittent intravenous bisphosphonate is a useful alternative, but this route is not readily available. Neridronate, a ni...

The use of intravenous aminobisphosphonates for the treatment of Paget's disease of bone.

Mini Rev. Med. Chem. 9(9) , 1052-63, (2009)

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil, a widely used immunosuppressant. Numerous studies have developed limited sampling strategies (LSSs) to predict MPA AUC in sol...


More Articles

Related Compounds

  • Neridronate sodium
  • 1-(2-Chloro-1,3-thiazol-5-yl)-2-(methylamino)ethan-1-ol
  • [2-(1-Ethynylcyclopropyl)ethenyl]benzene
  • 4-[2-chloro-5-(trifluoromethyl)-3-pyridyl]butan-2-ol
  • 1-Amino-2-(2-fluoro-3-methylphenyl)propan-2-ol
  • 2,4-Dimethoxypyridine-3-thiol
  • 5-{[1-(Hydroxymethyl)cyclopropyl]methyl}thiophene-2-carbonitrile
  • N,N-DMT-d4 (fumarate)
  • methyl 3-amino-2-(2-chloro-6-hydroxy-phenyl)propanoate
  • 5-Phenylbicyclo[3.1.1]heptane-1-carboxylic acid
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-7-carboxylate
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