4,4'-Sulfonyldiphenol

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Names

[ CAS No. ]:
80-09-1

[ Name ]:
4,4'-Sulfonyldiphenol

[Synonym ]:
phenol, 4,4'-sulfonyldi-
MFCD00002350
EINECS 201-250-5
4,4'-Sulfonyldiphenol
Phenol, 4,4'-sulfonylbis-
4-(4-hydroxyphenyl)sulfonylphenol
4,4'-Sulphonyldiphenol

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
505.3±35.0 °C at 760 mmHg

[ Melting Point ]:
245-250 °C(lit.)

[ Molecular Formula ]:
C12H10O4S

[ Molecular Weight ]:
250.270

[ Flash Point ]:
259.4±25.9 °C

[ Exact Mass ]:
250.029984

[ PSA ]:
82.98000

[ LogP ]:
1.83

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.645

[ Stability ]:
Stable. Incompatible with strong bases, acid chloride, acid anhydrides, strong oxidizing agents.

[ Water Solubility ]:
1.1 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SM8925000
CHEMICAL NAME :
Phenol, 4,4'-sulfonyldi-
CAS REGISTRY NUMBER :
80-09-1
BEILSTEIN REFERENCE NO. :
2052954
LAST UPDATED :
199801
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C12-H10-O4-S
MOLECULAR WEIGHT :
250.28
WISWESSER LINE NOTATION :
QR DSWR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 601-05501,1974
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 601-05501,1974 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4556 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 601-05501,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534330
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534330
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534330
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4700 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555048
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>10250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 601-05501,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
>1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534330 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10530 mg/kg/13D-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534330

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
SM8925000

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Phenol
  • 1,2-Dichlorobenzene
  • Carbon
  • 4,4'-Dichlorodiphenyl sulfone
  • 4,4′-Thiodiphenol
  • 1,3-Benzenedisulfonic acid
  • 2-Chlorophenyl 4-chlorophenyl sulfone
  • 1-methoxy-4-(4-methoxyphenyl)sulfonylbenzene
  • [ethoxy(ethoxycarbonyl)chloromethyl]phosphonic dichloride
  • Salicylic acid

DownStream

  • 4,4'-Sulfonylbis(fluorobenzene)
  • 1-Prop-2-enoxy-4-(4-prop-2-enoxyphenyl)sulfonyl-benzene
  • 4,4'-Sulfonylbis(2,6-dibromophenol)
  • 2,6,2',6'-Tetranitro-4,4'-sulfonyl-di-phenol
  • Trinitrophenol
  • 4,4'-Diaminodiphenylsulfone
  • Sulfenone
  • 2,2'-[Sulfonylbis(4,1-phenyleneoxy)]diethanol
  • 4,4'-Sulfonylbis(2-aminophenol)
  • 4-[(4-Benzyloxyphenyl)sulfonyl]phenol

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Interferences in the direct quantification of bisphenol S in paper by means of thermochemolysis.

J. Chromatogr. A. 1275 , 70-7, (2013)

This article analyses the interferences in the quantification of traces of bisphenol S in paper by applying the direct analytical method "analytical pyrolysis gas chromatography mass spectrometry" (Py...

Determination of bisphenols in beverages by mixed-mode solid-phase extraction and liquid chromatography coupled to tandem mass spectrometry.

J. Chromatogr. A. 1422 , 230-8, (2015)

Facing growing restrictions on the use of bisphenol A in food contact materials, several bisphenol analogs are arising as major alternatives to replace this chemical in most of its applications. This ...

Derivatization of bisphenol A and its analogues with pyridine-3-sulfonyl chloride: multivariate optimization and fragmentation patterns by liquid chromatography/Orbitrap mass spectrometry.

Rapid Commun. Mass Spectrom. 29 , 1473-84, (2015)

Due to the growing restrictions on the use of bisphenol A (BPA), several other bisphenols are gaining importance as substitutes for BPA in a variety of applications. There is, therefore, a real need f...


More Articles

Related Compounds

  • 4,4'-sulfonyldiphenol
  • 4,4'-Sulfonyldiphenol-d8
  • 2,2'-Di-tert.-butyl-6,6'-dimethyl-4,4'-sulfonyldiphenol
  • 4,4'-(1,6-diphenyl-3,4-diaza-hexa-1,3,5-triene-1,6-diyl)-bis-morpholine
  • 4,4',4''-Methanetriyltribenzonitrile
  • 4,4'-Sulfonylbis(benzenemethanol)
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 1-(6-Chloro-5-methylpyridin-3-yl)-3-oxocyclobutane-1-carbonitrile
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide