1,3-Dimethyl-2-imidazolidinone

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Names

[ CAS No. ]:
80-73-9

[ Name ]:
1,3-Dimethyl-2-imidazolidinone

[Synonym ]:
DMI
1,3-DMI
karbomostsem
1,3-Dimethylethyleneurea
1,3-dimethylimidazolin-2-one
1,3-Dimethylimidazolidone
1,3-Dimethyl-2-imida
2-Imidazolidinone, 1,3-dimethyl-
1,3-dimethylimidazolidinone
1,3-Dimethylimidazolidin-2-one
1,3-Dimethyl-2-imidazolidone
rhonite1
1,3-Dimethylimidazolidin-2-on
dimethyl-2-imidazolidinone
EINECS 201-304-8
1,3-DIMETHYL-2-IMIDAZOLIDINONE,DMEU,pharmaceutical intermediate
Karbomos
MFCD00003188
N,N'-dimethylimidazolidinone
N,N'-dimethyl-2-imidazolidinone

Chemical & Physical Properties

[ Density]:
1.044

[ Boiling Point ]:
225.5 ºC

[ Melting Point ]:
8.2 °C

[ Molecular Formula ]:
C₅H₁₀N₂O

[ Molecular Weight ]:
114.146

[ Flash Point ]:
93 ºC

[ Exact Mass ]:
114.079315

[ PSA ]:
23.55000

[ LogP ]:
-0.03

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.480

[ Water Solubility ]:
freely soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ0660000

CHEMICAL NAME :: 2-Imidazolidinone, 1,3-dimethyl-

CAS REGISTRY NUMBER :: 80-73-9

BEILSTEIN REFERENCE NO. :: 0108808

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H10-N2-O

MOLECULAR WEIGHT :: 114.17

WISWESSER LINE NOTATION :: T5NVNTJ A1 C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,191,1992 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1190 uL/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - tremor Skin and Appendages - hair

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,191,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2840 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,214,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 930 uL/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - other changes

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,191,1992

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318-H361-H373

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Target Organs ]:
Testes

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R21/22;R36/38

[ Safety Phrases ]:
S26-S36-S36/37/39

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
NJ0660000

[ Hazard Class ]:
6.1

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

carbon monoxide
1,2-Dimethylethylenediamine
2-Imidazolidinone,1,3-bis(hydroxymethyl)-
Lauric acid
2-Chloro-1,3-dimethylimidazolidinium chloride
Carbon dioxide
nndimethylethylenethiourea
Cyclohexene oxide
2-Imidazolidinone
Dimethyl sulfate

DownStream

2-Chloro-1,3-dimethylimidazolidinium chloride
2-(2-NAPHTHYL)-1H-BENZIMIDAZOLE
1-Chloro-3,5-difluorobenzene
Sodium formate
1,2-Dimethylethylenediamine
[2.2]Paracyclophane
2-Chloro-1,3-dimethylimidazolidinium hexafluorophosphate
4-methoxy-2-methylquinolin-8-ol
3,4-Difluorosalicylic acid
Entinostat (MS-275)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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