Quinine sulfate
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Names
[ CAS No. ]:
804-63-7
[ Name ]:
Quinine sulfate
[Synonym ]:
quinine hydrogen sulphate
(8α,9R)-6'-Methoxycinchonan-9-ol sulfate (1:1)
Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-, sulfate (1:1) (salt)
EINECS 212-359-2
MFCD00078499
Quinine hydrogen sulfate
Quinine sulphate
chinidinesulfate
Quinine sulfate
Chemical & Physical Properties
[ Boiling Point ]:
911.6ºC at 760 mmHg
[ Molecular Formula ]:
C20H26N2O6S
[ Molecular Weight ]:
422.495
[ Flash Point ]:
505.1ºC
[ Exact Mass ]:
422.151154
[ PSA ]:
128.57000
[ LogP ]:
3.53910
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA8440000
- CHEMICAL NAME :
- Quinine, sulfate
- CAS REGISTRY NUMBER :
- 804-63-7
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C20-H24-N2-O2.1/2H2-O4-S
- MOLECULAR WEIGHT :
- 420.52
- WISWESSER LINE NOTATION :
- T66 BNJ HO1 EYQ- DT66 A B CNTJ A1U1 &WSQQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 45455 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Kidney, Ureter, Bladder - renal function tests depressed
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 6500 ug/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Kidney, Ureter, Bladder - interstitial nephritis
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - change in acuity Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 129 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 27 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Ear) - tinnitus Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 12 mg/kg/1D-I
- TOXIC EFFECTS :
- Liver - hepatitis, fibrous (cirrhosis, post-necrotic scarring)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 220 mg/kg
- TOXIC EFFECTS :
- Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema Blood - changes in spleen
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 4300 ug/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Blood - agranulocytosis
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Ear) - change in acuity Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 126 mg/kg/3W-I
- TOXIC EFFECTS :
- Cardiac - cardiomyopathy including infarction Skin and Appendages - dermatitis, allergic (after systemic exposure)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1425 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating - 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical
MUTATION DATA
- TYPE OF TEST :
- Phage inhibition capacity
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,2819,1983 *** REVIEWS *** TOXICOLOGY REVIEW PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933- Volume(issue)/page/year: 213,159,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80205 No. of Facilities: 92 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 460 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80205 No. of Facilities: 82 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1305 (estimated) No. of Female Employees: 678 (estimated)
Safety Information
[ RIDADR ]:
UN 1544
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)