Iron sucrose

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Names

[ CAS No. ]:
8047-67-4

[ Name ]:
Iron sucrose

[Synonym ]:
Venofer
ferrivenin
Sucrofer
EINECS 232-464-7
MFCD00166305
Fesin
Hippiron
Iron(3+) D-glucarate (2:3)
ironsugar
iviron
proferrin
feojectin

Chemical & Physical Properties

[ Boiling Point ]:
766.4ºC at 760 mmHg

[ Melting Point ]:
MORE THAN 51ºC

[ Molecular Formula ]:
C18H24Fe2O24

[ Molecular Weight ]:
736.059

[ Flash Point ]:
431.2ºC

[ Exact Mass ]:
735.935608

[ PSA ]:
483.54000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NO7700000
CHEMICAL NAME :
Iron oxide, saccharated
CAS REGISTRY NUMBER :
8047-67-4
LAST UPDATED :
199512

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,193,1982
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
150 mg(Fe)/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 10,375,1955 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1560 mg/kg/13W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 60,708,1989
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
148 gm/kg/74W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,947,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
104 gm/kg/13W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 24,109,1960
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 gm/kg/I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - lymphoma, including Hodgkin's disease Tumorigenic - tumors at site of application
REFERENCE :
BECCAN Annual Report--Cancer Research Campaign. (Cancer Research Campaign, 2 Carlton House Terrace, London SW1Y 5AR, UK) V.1- 1924- Volume(issue)/page/year: 40,30,1962 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 2,161,1973 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 2,161,1973 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year: 12,102,1969

Safety Information

[ HS Code ]:
3004909090

Customs

[ HS Code ]: 3004909090

Related Compounds

  • Iron, glycerol sucrose complexes
  • iron(iii) citrate hydrate, 98
  • IRON SILICIDE
  • iron,samarium (7:2)
  • Iron chloride oxide
  • Iron(2+),tris(2,2'-bipyridine-N,N')-, diiodide, (OC-6-11)- (9CI)
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  • 4-Acetamido-2-(methylsulfanyl)-1,3-thiazole-5-carboxylic acid
  • tert-butyl N-(5-ethynyl-6-methylpyridin-3-yl)carbamate
  • tert-butyl N-[(2-chloro-1,3-oxazol-4-yl)methyl]carbamate
  • 2,2-Difluoro-1-(2,2,2-trifluoroacetamido)cyclopropane-1-carboxylic acid
  • 1-(2,2-difluoroethyl)-3-acetamido-1H-pyrazole-5-carboxylic acid
  • (1S)-2-cyclopropyl-1-{5-methylfuro[3,2-b]pyridin-2-yl}ethan-1-amine
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 4-[(2-cyanophenyl)carbamoyl]butanoate
  • (3S)-4-(tert-butoxy)-3-(carboxyamino)-4-oxobutanoic acid
  • 1-Acetyl-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylic acid