MEGESTROL ACETATE + ETHINYLO-ESTRADIOL

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Names

[ CAS No. ]:
8064-66-2

[ Name ]:
MEGESTROL ACETATE + ETHINYLO-ESTRADIOL

[Synonym ]:
Oraconal

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₄H₅₆O₆

[ Molecular Weight ]:
680.91200

[ Exact Mass ]:
680.40800

[ PSA ]:
100.90000

[ LogP ]:
8.18790

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4140000

CHEMICAL NAME :: Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-, acetate mixed with 19-nor-17-alpha- pregna-1,3,5(10)-trien-2-yne-3,17-diol

CAS REGISTRY NUMBER :: 8064-66-2

LAST UPDATED :: 198910

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C24-H32-O4.C20-H24-O2

MOLECULAR WEIGHT :: 681.00

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 10584 ug/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - normocytic anemia

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,273,1980

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 41 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 4,496,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2430 ug/kg

SEX/DURATION :: female 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,1318,1963

Related Compounds

Megestrol Acetate EP Impurity C
Megestrol Acetate
Megestrol acetate-d3
Megestrol acetate
[(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate,(8R,9S,13S,14S,17R)-17-ethynyl-3-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol
tetrahydropyrethrolone acetate
3-{1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]piperidin-2-yl}propanoic acid
3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-(1,2-oxazolidin-2-yl)-4-oxobutanoic acid
2-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-2-methylbutanamido}acetic acid
5-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido]acetamido}hexanoic acid
(2S)-3-(tert-butoxy)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-methoxypropanamido]propanoic acid
(2S)-2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-1,3-thiazol-5-yl]formamido}-3-methoxypropanoic acid
2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-(2-hydroxyethyl)-3-methoxypropanamido]acetic acid
(2R,4R)-1-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido]acetyl}-4-hydroxypyrrolidine-2-carboxylic acid
2-cyclobutyl-2-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]acetic acid
(2R,3S)-3-(benzyloxy)-2-{[(1RS,3RS,5RS)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)bicyclo[3.1.0]hexan-1-yl]formamido}butanoic acid

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