(3α,5α)-3-Hydroxy-11,20-dioxopregnan-21-yl acetate-(3α,5α)-3-hy droxypregnane-11,20-dione (1:1)

Names

[ CAS No. ]:
8067-82-1

[ Name ]:
(3α,5α)-3-Hydroxy-11,20-dioxopregnan-21-yl acetate-(3α,5α)-3-hy droxypregnane-11,20-dione (1:1)

Chemical & Physical Properties

[ Boiling Point ]:
523.6ºC at 760 mmHg

[ Molecular Formula ]:
C₄₄H₆₆O₈

[ Molecular Weight ]:
722.99000

[ Flash Point ]:
175.1ºC

[ Exact Mass ]:
722.47600

[ PSA ]:
135.04000

[ LogP ]:
7.09160

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4158100

CAS REGISTRY NUMBER :: 8067-82-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C23-H34-O5.C21-H32-O3

MOLECULAR WEIGHT :: 723.10

WISWESSER LINE NOTATION :: L E5 B666 CVTJ A1 E1 FV1OV1 OQ &L E5 B666 CVTJ A1 E1 FV1 OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes

REFERENCE :: PRACAK Practitioner. (Morgan-Grampian Ltd., 40 Beresford St., Woolwich, London SE18 6BQ, UK) V.1- 1868- Volume(issue)/page/year: 222,249,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 32,375,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 1,119,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: JEMAAJ Journal of the Egyptian Medical Association. (Egyptian Medical Assoc., 42, Sharia Kasr-El- Aini, Cairo, Egypt) V.11- 1928- Volume(issue)/page/year: 62,191,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes

REFERENCE :: JEMAAJ Journal of the Egyptian Medical Association. (Egyptian Medical Assoc., 42, Sharia Kasr-El- Aini, Cairo, Egypt) V.11- 1928- Volume(issue)/page/year: 62,191,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PESTD5 Proceedings of the European Society of Toxicology. (Amsterdam, Netherlands) V.16-18, 1975-77. Discontinued. Volume(issue)/page/year: 16,208,1975 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 35 mL/kg

SEX/DURATION :: female 9-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year: 1,165,1975

Related Compounds

2-Amino-3-(2-methoxyethylamino)phenol
[1-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)ethyl](ethyl)amine
4-Bromo-2-fluoro-N-(2-morpholinoethyl)benzamide
2,6-dichloro-3-[N-methyl-N-(phthalimidoacetyl)amino]benzyl methanesulfonate
2-cyclopropyl-2,3-dihydro-1H-isoindol-4-amine
1-(1,2,3,4-Tetrahydronaphthalen-1-yl)-1H-pyrazol-5-amine
5-Fluoro-2-[[3-(1H-imidazol-1-yl)-1-oxopropyl]amino]benzoic acid
2-(Sulfamoylamino)propanoic acid
3-Isocyanato-2,5-dimethylfuran
2-(2-Bromo-4-fluorophenoxy)-4-pyridinecarbonitrile

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