alpha-(Trichloromethyl)-2-pyridinemethanol

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Names

[ CAS No. ]:
80673-02-5

[ Name ]:
alpha-(Trichloromethyl)-2-pyridinemethanol

[Synonym ]:
2-Pyridyltrichloromethyl carbinol
2-Pyridinemethanol,a-(trichloromethyl)
2,2,2-trichloro-1-(pyridin-2-yl)ethan-1-ol

Chemical & Physical Properties

[ Density]:
1.531g/cm3

[ Boiling Point ]:
302ºC at 760 mmHg

[ Molecular Formula ]:
C7H6Cl3NO

[ Molecular Weight ]:
226.48800

[ Flash Point ]:
136.4ºC

[ Exact Mass ]:
224.95100

[ PSA ]:
33.12000

[ LogP ]:
2.48520

[ Index of Refraction ]:
1.59

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT5036700
CHEMICAL NAME :
2-Pyridinemethanol, alpha-(trichloromethyl)-
CAS REGISTRY NUMBER :
80673-02-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H6-Cl3-N-O
MOLECULAR WEIGHT :
226.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 16,533,1981

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Pyridinecarboxaldehyde
  • Sodium TCA
  • Chloroform
  • 2-(2,2,2-trichloro-1-((trimethylsilyl)oxy)ethyl)pyridine
  • 2-(Trimethylsilyl)pyridine

DownStream

  • Ethanone, 2-chloro-1-(2-pyridinyl)- (9CI)

Related Compounds

  • 2-Furanmethanol,5-(diethylamino)--alpha--(trichloromethyl)-
  • alpha-(trichloromethyl)benzyl propionate
  • alpha-((2-(Dimethylamino)ethoxy)methyl)-3-pyridinemethanol dihydrochlo ride
  • alpha-[2-(1-pyrrolidinyl)ethyl]-alpha-(p-tolyl)pyridine-2-methanol
  • alpha-[2-[bis(isopropyl)amino]ethyl]-alpha-isobutylpyridine-2-acetonitrile
  • alpha-(2,4-Dichlorophenyl)-alpha-(4-fluorophenyl)-1H-1,2,4-triazole-1-ethanol
  • (3S,3'S,4'R)-Idoxanthin
  • N-[2-({[3-(4-morpholinyl)propyl]amino}carbonyl)phenyl]nicotinamide
  • (R)-3-Hydroxy-4-phenylbutanoic acid
  • 4-(((Tert-butyldimethylsilyl)oxy)methyl)-2-chloro-3-methylpyridine
  • 4-Phenylfluoren-9-one
  • 4-(4-methylphenyl)-3-[[4-(4-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-1H-1,2,4-triazole-5-thione
  • 4-Methyl-5-trimethylsilylthiophene-2-carbaldehyde
  • 1-(6-methoxy-2,2,4-trimethylquinolin-1(2H)-yl)-2-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]ethanone
  • 4-Chloro-1-propyl-1H-pyrazol-3-amine
  • 8-Chloro-4-(3-methyl-1-piperazinyl)benzofuro[3,2-d]pyrimidine
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