SKF 83959 HYDROBROMIDE

Names

[ CAS No. ]:
80751-85-5

[ Name ]:
SKF 83959 HYDROBROMIDE

[Synonym ]:
6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol

Chemical & Physical Properties

[ Density]:
1.249g/cm3

[ Boiling Point ]:
464.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₁BrClNO₂

[ Molecular Weight ]:
398.72200

[ Flash Point ]:
234.8ºC

[ Exact Mass ]:
397.04400

[ PSA ]:
43.70000

[ LogP ]:
4.57540

[ Index of Refraction ]:
1.619

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

SKF83959 is a potent allosteric modulator of sigma-1 receptor.

Mol. Pharmacol. 83(3) , 577-86, (2013)

SKF83959 (3-methyl-6-chloro-7,8-hydroxy-1-[3-methylphenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine), an atypical dopamine receptor-1 (D(1) receptor) agonist, has shown many D(1) receptor-independent effec...

The D₁ dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways.

Mol. Vis. 18 , 2882-95, (2012)

Oxidative stress is widely implicated in the death of retinal ganglion cells associated with various optic neuropathies. Agonists of the dopamine D(1) receptor have recently been found to be potential...

Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses.

Neuropharmacology 57(2) , 164-71, (2009)

Recent work has demonstrated that a phosphatidylinositol (PI)-linked D(1) dopamine receptor selective agonist, SKF83959, mediates phosphatidylinositol hydrolysis via activation of phospholipase C(beta...

SKF 83959 HYDROBROMIDE

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Names

Chemical & Physical Properties

MSDS

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Safety Information

Articles

Related Compounds