4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one

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Names

[ CAS No. ]:
80841-78-7

[ Name ]:
4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one

[Synonym ]:
4-chloromethyl-5-methyl-2-oxo-1,3-dioxolene
4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one
4-chloromethyl-5-methyl-1,3-dioxolen-2-one
MFCD07787494
DMDO-CL
4-ChloroMethyl-5-Methyl-1
4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE
T5OVOJ D1G E1
medoxomil chloride
4-methyl-5-chloro methyl-1,3-dioxol-2-one
1,3-Dioxol-2-one, 4-(chloromethyl)-5-methyl-
4-Chloromethyl-5-methyl-1,3-dioxol-2-on
4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-3-ONE
4-CHLOROMETHYL-5-METHYL-2-OXO-1,3-DIOXOLE
4-Chloromethyl-5-Methyl-1,3-Di
4-Choromethyl-5-methyl-2-oxo-1,3-dioxole

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
163.2±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C5H5ClO3

[ Molecular Weight ]:
148.544

[ Flash Point ]:
66.7±26.9 °C

[ Exact Mass ]:
147.992722

[ PSA ]:
43.35000

[ LogP ]:
1.61

[ Vapour Pressure ]:
2.1±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.481

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4,5-Dimethyl-1,3-dioxol-2-one
  • 4-chloro-4-methyl-5-methylidene-1,3-dioxolan-2-one

DownStream

  • Trityl Olmesartan Medoxomil
  • 4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methylthio)benzenesulfonate
  • (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-4-carboxylate
  • 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
  • 4-(Bromomethyl)-5-methyl-1,3-dioxol-2-one
  • Azilsartan medoxomil
  • Prulifloxacin
  • Olmesartan medoxomil
  • Trityl Olmesartan Medoxomil

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and Physicochemical Characterization of the Process-Related Impurities of Olmesartan Medoxomil. Do 5-(Biphenyl-2-yl)-1-triphenylmethyltetrazole Intermediates in Sartan Syntheses Exist?

Molecules 20 , 21346-63, (2015)

During the process development for multigram-scale synthesis of olmesartan medoxomil (OM), two principal regioisomeric process-related impurities were observed along with the final active pharmaceutic...


More Articles

Related Compounds

  • 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
  • 4-(Bromomethyl)-5-methyl-1,3-dioxol-2-one
  • 4-(iodomethyl)-5-methyl-1,3-dioxol-2-one
  • 4-tert-butyl-5-methyl-1,3-dioxol-2-one
  • 4-(2-bromoethyl)-5-methyl-1,3-dioxol-2-one
  • 4-(4-fluorophenyl)thiomethyl-5-methyl-1,3-dioxol-2-one
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • N-(3-methylisothiazol-5-yl)-2-(6-oxo-4-(thiophen-2-yl)pyrimidin-1(6H)-yl)acetamide
  • N-[(2,4-dichlorophenyl)methyl]-6-methoxy-5-(4-methyl-1h-imidazol-1-yl)-2-pyridinecarboxamide
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 6-Pyrazolo[1,5-a]pyrimidin-6-yl-4-(4-pyridinyl)quinoline