1,8-Naphthalic anhydride

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Names

[ CAS No. ]:
81-84-5

[ Name ]:
1,8-Naphthalic anhydride

[Synonym ]:
1H,3H-Benzo[de]isochromene-1,3-dione
1,8-naphthalene dicarboxylic anhydride
1H,3H-naphtho [1,8-cd]pyran-1,3-dione
Protect
naphthalic
1,8-naphthalic anhydride
MFCD00006925
NAPHTHALIC ANHYDRIDE
PROTECT(R)
naphthalene-1,8-dicarboxylic acid anhydride
1H,3H-Naphtho[1,8-cd]pyran-1,3-dione
1,8-Naphthalic
EINECS 201-380-2
1,8-Naphthalenedicarboxylic acid anhydride
pakarli
naphthalene-1,8-dicarboxylic anhydride
1,8-dinaphthoic anhydride
1H,3H-Naphtho(1,8-cd)pyran-1,3-dione (9CI)
1,8-Naphthalic anhyd
protect(agrochemical)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
407.5±14.0 °C at 760 mmHg

[ Melting Point ]:
269 °C

[ Molecular Formula ]:
C₁₂H₆O₃

[ Molecular Weight ]:
198.174

[ Flash Point ]:
206.8±17.3 °C

[ Exact Mass ]:
198.031693

[ PSA ]:
43.37000

[ LogP ]:
1.75

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.712

[ Water Solubility ]:
decomposes

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK5350000

CHEMICAL NAME :: 1,8-Naphthalic anhydride

CAS REGISTRY NUMBER :: 81-84-5

BEILSTEIN REFERENCE NO. :: 0153190

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C12-H6-O3

MOLECULAR WEIGHT :: 198.18

WISWESSER LINE NOTATION :: T666 1A M CVOVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12340 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C253,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533580

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533580

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533580

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2025 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 8,590,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 8,590,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >6810 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 8,590,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 2 mg/m3;Skin JAN 1993

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
QK5350000

[ Hazard Class ]:
4.1

[ HS Code ]:
29173980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Acenaphthene
Acenaphthoquinone
1,8-DIIODONAPHTHALENE
carbon monoxide
N,O-Dimethylhydroxylamine hydrochloride
(2-METHOXYVINYL)BENZENE
2-benzylideneacenaphthylen-1-one
tert-Butylamine
ISOBUTYL VINYL ETHER
Ethyl 2-oxo-3'-phenylspiro[acenaphthylene-1-(2H),5'(4'H)-isoxazole]-4'-carboxylate

DownStream

1H-Benz[de]isoquinoline-1,3(2H)-dione,2-(2-hydroxyethyl)-
4-bromo-3-nitro-1,8-naphthalic anhydride
10-Methoxy-7H-benzimidazo[2,1-a]benz[de]isoquinolin-7-one
11-methoxy-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one
Alrestatin
6-(1,3-DIOXO-1H-BENZO[DE]ISOQUINOLIN-2(3H)-YL)HEXANOIC ACID
1,8-Naphthalenedimethanol
1-Naphthalenecarboxylic acid, 8-(hydroxymethyl)-, .delta.-lactone
1,8-bis(chloromethyl)naphthalene
2,2-dimethylphenalene-1,3-dione

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

1,8-Naphthalic anhydride antidote enhances the toxic effects of captan and thiram fungicides on Azospirillum brasilense cells.

Res. Microbiol. 142(9) , 1005-12, (1991)

The effects of ten fungicides, six herbicides and four insecticides on the nitrogen-fixing bacterium Azospirillum brasilense were examined. The fungicides captan and thiram were the most toxic among t...

Sensitive enantiomeric separation of aliphatic and aromatic amines using aromatic anhydrides as nonchiral derivatizing agents.

J. Chromatogr. A. 666 , 485-491, (1994)

New pre-column derivatizing reagents: phthalic anhydride, 3-nitrophthalic anhydride, diphenic anhydride, 1,8-naphthalic anhydride and diphenylmaleic anhydride have been developed for resolving chiral ...

Differential induction of cytochrome P450-mediated triasulfuron metabolism by naphthalic anhydride and triasulfuron.

Plant Physiol. 109(4) , 1483-90, (1995)

Cytochrome P450 monooxygenases play paramount roles in the detoxification of herbicides as well as in the synthesis of lignins, flavonoids, and phenolic acids. Biochemical analysis of triasulfuron met...