L-741,626

Suppliers

Names

[ Name ]:
L-741,626

[Synonym ]:
4-(4-Chlorophenyl)-1-(1H-indol-3-ylmethyl)-4-piperidinol
L 741,626
1-(indol-3-ylmethyl)-4-hydroxy-4-(p-chlorophenyl)piperidine
4-Piperidinol,4-(4-chlorophenyl)-1-(1H-indol-3-ylmethyl)
3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole

Chemical & Physical Properties

[ Density]:
1.311g/cm3

[ Boiling Point ]:
548.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₁ClN₂O

[ Molecular Weight ]:
340.84700

[ Flash Point ]:
285.7ºC

[ Exact Mass ]:
340.13400

[ PSA ]:
39.26000

[ LogP ]:
4.24280

[ Index of Refraction ]:
1.686

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Indole
4-(4-Chlorophenyl)-4-piperidinol
Gramine

DownStream

Articles

Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma.

Oncotarget 5(4) , 882-93, (2014)

Glioblastoma remains one of the deadliest of human cancers, with most patients succumbing to the disease within two years of diagnosis. The available data suggest that simultaneous inactivation of cri...

3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.

J. Med. Chem. 39 , 1941, (1996)

The role of the dopamine D2 receptor in descending control of pain induced by motor cortex stimulation in the neuropathic rat.

Brain Res. Bull. 89(3-4) , 133-43, (2012)

We studied in rats with a spinal nerve ligation-induced neuropathy whether dopamine D2 receptors (D2Rs) play a role in descending control of pain induced by stimulation of the primary motor cortex (M1...

L-741,742 hydrochloride,5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazolehydrochloride
5-[[3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenylpiperidin-1-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
L-741,742 hydrochloride
L-Malic acid dipotassium
L-Cysteine,S-(aminocarbonyl)-
L-Serine-13C3,15N
1-(Isocyanomethyl)-3-(methoxymethyl)benzene
2-(4-Methyloxan-4-yl)prop-2-enoic acid
1-(1,3-Oxazol-5-yl)prop-2-en-1-one
3-{3-[(Dimethylamino)methyl]phenyl}prop-2-enal
3-{3-[(Dimethylamino)methyl]phenyl}-2,2-dimethylpropan-1-amine
5-[1-(2-methylpropyl)-1H-pyrazol-4-yl]-1,3-oxazolidin-2-one
2-Hydroxy-3-(thiolan-2-yl)propanoic acid
1-{3-[(Dimethylamino)methyl]phenyl}-2-methylpropan-2-ol
2,2-dimethyl-1-[1-(2-methylpropyl)-1H-pyrazol-4-yl]cyclopropan-1-amine
methyl 3-hydroxy-3-[1-(2-methylpropyl)-1H-pyrazol-4-yl]propanoate

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