Acrylyl chloride

Names

[ CAS No. ]:
814-68-6

[ Name ]:
Acrylyl chloride

[Synonym ]:
2-Propenoyl chloride
prop-2-enoyl chloride
Prop-2-enoylchlorid
MFCD00000731
PROPENOYL CHLORIDE
EINECS 212-399-0
Acryloyl chloride

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
75.5±0.0 °C at 760 mmHg

[ Melting Point ]:
72-76ºC

[ Molecular Formula ]:
C₃H₃ClO

[ Molecular Weight ]:
90.508

[ Flash Point ]:
16.1±0.0 °C

[ Exact Mass ]:
89.987244

[ PSA ]:
17.07000

[ LogP ]:
1.06

[ Vapour density ]:
>1 (vs air)

[ Vapour Pressure ]:
104.8±0.1 mmHg at 25°C

[ Index of Refraction ]:
1.417

[ Stability ]:
Stable, but reacts violently with water. Incompatible with alcohols, oxidizing agents, strong bases. Light-sensitive. Highly flammable.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AT7350000

CHEMICAL NAME :: Acryloyl chloride

CAS REGISTRY NUMBER :: 814-68-6

BEILSTEIN REFERENCE NO. :: 0635744

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C3-H3-Cl-O

MOLECULAR WEIGHT :: 90.51

WISWESSER LINE NOTATION :: GV1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - iritis Behavioral - ataxia Lungs, Thorax, or Respiration - emphysema

REFERENCE :: BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- Volume(issue)/page/year: 27,1,1970

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 92 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,17,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03367 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.3 mg/m3;Skin JAN 1993

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H314-H330

[ Precautionary Statements ]:
P210-P260-P280-P284-P305 + P351 + P338-P310

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R11;R34

[ Safety Phrases ]:
S16-S26-S28-S36/37/39-S45-S7/9

[ RIDADR ]:
UN 3383 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
AT7350000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
2916190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

naphthalen-2-yl prop-2-enoate
naphthalen-2-yl 3-chloropropanoate
12-bromododecyl prop-2-enoate
d-menthyl acrylate
4,4-dimethyl-3-prop-2-enoyl-1,3-oxazolidin-2-one
1h,1h-perfluorooctyl acrylate
N-acryloxysuccinimide
1H,1H-PERFLUORO-N-DECYL ACRYLATE
Diethylene glycol diacrylate
Ethyl 3-(diethoxyphosphoryl)propanoate

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

iRGD conjugated TPGS mediates codelivery of paclitaxel and survivin shRNA for the reversal of lung cancer resistance.

Mol. Pharm. 11(8) , 2579-91, (2014)

Multidrug resistance (MDR) is one of the major obstacles in tumor treatment. Herein, we reported an active targeting strategy with peptide-mediated nanoparticles deep into tumor parenchyma, which iRGD...

Controlling osteogenic stem cell differentiation via soft bioinspired hydrogels.

PLoS ONE 9(6) , e98640, (2014)

Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is guided by various physical and biochemical factors. Among these factors, modulus (i.e., rigidiy) of the ECM has gained significant...

Effect of Relative Arrangement of Cationic and Lipophilic Moieties on Hemolytic and Antibacterial Activities of PEGylated Polyacrylates.

Int. J. Mol. Sci. 16 , 23867-80, (2015)

Synthetic amphiphilic polymers have been established as potentially efficient agents to combat widespread deadly infections involving antibiotic resistant superbugs. Incorporation of poly(ethylene gly...