Alfuzosin hydrochloride

Suppliers

Names

[ Name ]:
Alfuzosin hydrochloride

[Synonym ]:
SL 77 499-10
N-{3-[(4-amino-6,7-diméthoxyquinazolin-2-yl)(méthyl)amino]propyl}tétrahydrofurane-2-carboxamide chlorhydrate
Uroxatral
MFCD00879135
N-{3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)(methyl)amino]propyl}tetrahydro-2-furancarboxamide hydrochloride (1:1)
2-furancarboxamide, N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-, monohydrochloride
Alfuzosin HCl
N-{3-[(4-Amino-6,7-dimethoxychinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamidhydrochlorid
2-Furancarboxamide, N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-, hydrochloride (1:1)
SL 77-499-10
Alfuzosin hydrochloride
N-{3-[(4-Amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide hydrochloride (1:1)
Alfuzosin (hydrochloride)

Chemical & Physical Properties

[ Density]:
1.272 g/cm3

[ Boiling Point ]:
687.7ºC at 760 mmHg

[ Melting Point ]:
225°C

[ Molecular Formula ]:
C₁₉H₂₈ClN₅O₄

[ Molecular Weight ]:
425.910

[ Exact Mass ]:
425.182983

[ PSA ]:
111.83000

[ LogP ]:
3.12480

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Alfuzosin
N1-methyl-N1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine
1-(tetrahydrofuran-2-ylcarbonyl)-1H-imidazole
Tetrahydro-2-furancarbonyl chloride
2-Tetrahydrofuroic acid
PHYTASE
N-[3-(methylamino)propyl]oxolane-2-carboxamide
2-Chloro-6,7-dimethoxyquinazolin-4-amine
(R,S)-N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide acetate

DownStream

Articles

Comparison ofcore–shelland totally porous ultra high performance liquid chromatographic stationary phases based on their selectivity towards alfuzosin compounds

J. Chromatogr. A. 1346 , 69-77, (2014)

• KUL procedure was adapted to testing of UHPLC stationary phases. • Classification of core–shell and UHPLC columns was performed. • Verification of the KUL results was based on the separation of alfu...

Temperature influencing permeation pattern of alfuzosin: an investigation using DoE.

Medicina (Kaunas.) 51 , 253-61, (2015)

There has been relatively little investigation of the effect of temperature on skin permeation compared to other methods of penetration enhancement. A principal physicochemical factor which controls t...

N2-Methyl Alfuzosin Hydrochloride
Alfuzosin hydrochloride impurity A
2,3,4,5-tetradehydro alfuzosin hydrochloride
2,3,4,5-Tetradehydro Alfuzosin Hydrochloride
Alfuzosin-d3 hydrochloride
Alfuzosin-d3
2-{[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]methyl}cyclopentane-1-carboxylic acid
3-({2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)-2-methylpropanoic acid
4-[N-ethyl1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopropaneamido]oxolane-3-carboxylic acid
4-[N-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanamido]oxolane-3-carboxylic acid
4-[(2S)-N-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]oxolane-3-carboxylic acid
3-{[3-bromo-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)phenyl]formamido}-2-hydroxypropanoic acid
4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentanecarbonyl]morpholine-3-carboxylic acid
2-{1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentanecarbonyl]pyrrolidin-3-yl}acetic acid
3-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]formamido}-2-hydroxy-2-methylpropanoic acid
3-{2-[1-benzyl-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)piperidin-4-yl]acetamido}-3-methylbutanoic acid

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