Caracemide

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Names

[ CAS No. ]:
81424-67-1

[ Name ]:
Caracemide

[Synonym ]:
N-Acetyl-N-(methylcarbamoyloxy)-N'-methylurea
N-((methylamino)carbonyl)-N-(((methylamino)carbonyl)oxy)acetamide

Chemical & Physical Properties

[ Density]:
1.259g/cm3

[ Molecular Formula ]:
C6H11N3O4

[ Molecular Weight ]:
189.16900

[ Exact Mass ]:
189.07500

[ PSA ]:
87.74000

[ LogP ]:
0.22710

[ Index of Refraction ]:
1.479

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC5961200
CHEMICAL NAME :
Acetamide, N-((methylamino)carbonyl)-N-(((methylamino)carbonyl)o xy)-
CAS REGISTRY NUMBER :
81424-67-1
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C6-H11-N3-O4
MOLECULAR WEIGHT :
189.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
388 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
167 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
238 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
50 umol/L
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 35,27,1988

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acetohydroxamic acid
  • Methylisocyanate 1 x 500mg neat

DownStream

Related Compounds

  • 4-Ethyl-3-methyl-6-({1-[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-4-yl}methoxy)pyridazine
  • 5-(5-{2-methyl-5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}-octahydropyrrolo[3,4-c]pyrrol-2-yl)pyridine-2-carbonitrile
  • 4-[4-(3-Bromophenyl)piperazin-1-yl]pyridine-2-carboxamide
  • N-tert-butyl-1-(9H-purin-6-yl)pyrrolidine-3-carboxamide
  • 5-fluoro-N-(1-methyl-1H-pyrazol-3-yl)pyridine-3-carboxamide
  • 5-Methyl-4-(4-{[2-(trifluoromethyl)phenyl]methyl}piperazin-1-yl)pyrimidine
  • 3-(2-Methoxyethyl)-1-[1-(quinoxalin-2-yl)piperidin-4-yl]imidazolidine-2,4-dione
  • 2-cyclopropyl-N-[(2-fluorophenyl)methyl]-6-(oxan-4-yl)pyrimidin-4-amine
  • 2-Tert-butyl-4,5-dimethyl-6-({1-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]piperidin-4-yl}methoxy)pyrimidine
  • 1-[1-(6-Chloro-1,3-benzothiazol-2-yl)piperidin-4-yl]-3-(2-methoxyethyl)imidazolidine-2,4-dione
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