1-Bromo-2-butanone

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Names

[ CAS No. ]:
816-40-0

[ Name ]:
1-Bromo-2-butanone

[Synonym ]:
1-Bromo-2-butanone
2-Butanone, 1-bromo-
MFCD00000207
1-bromobutan-2-one
EINECS 212-431-3

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
155.9±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C4H7BrO

[ Molecular Weight ]:
151.002

[ Flash Point ]:
68.3±0.0 °C

[ Exact Mass ]:
149.968018

[ PSA ]:
17.07000

[ LogP ]:
1.07

[ Vapour Pressure ]:
3.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.453

[ Storage condition ]:
Keep Cold

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EL7000000
CHEMICAL NAME :
2-Butanone, 1-bromo-
CAS REGISTRY NUMBER :
816-40-0
BEILSTEIN REFERENCE NO. :
0741894
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C4-H7-Br-O
MOLECULAR WEIGHT :
151.02
WISWESSER LINE NOTATION :
E1V2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/m3/10M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: No.9-4-1-9,1943

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn,Xi,F

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S27-S36/37/39

[ RIDADR ]:
1693

[ WGK Germany ]:
3

[ RTECS ]:
EL7000000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Butanone
  • (TRIMETHYLSILYLMETHYL) ETHYL KETONE
  • 3-Chloro-2-butanone
  • Petasis reagent
  • N,N-Diethylpropionamide
  • N,N-Dipropylpropionamide
  • 1-Propanone,1-(4-morpholinyl)-
  • N,N-Dimethylpropanamide
  • 1-pyrrolidin-1-yl-propan-1-one
  • N,N-Pentamethylenepropionamide

DownStream

  • 1-HYDROXY-2-BUTANONE
  • 8-bromo-3-methyl-7-(2-oxobutyl)purine-2,6-dione
  • 5-ethyl-2-phenyl-1H-imidazole
  • 1-Acetoxy-2-butanone
  • 4-ethyl-3H-1,3-thiazole-2-thione
  • 2,4-Diethylthiazole
  • Butyric acid, thio-, S-ester with 1-mercapto-2-butanone
  • 4-ethyl-1,3-thiazol-2-amine(SALTDATA: HCl 0.7H2O)
  • 1-(benzenesulfonyl)butan-2-one
  • DIETHYL (2-OXOBUTYL)PHOSPHONATE

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Microwave-assisted preparation of fused bicyclic heteroaryl boronates: application in one-pot Suzuki couplings.

J. Org. Chem. 71 , 3959, (2006)

The rapid and efficient synthesis of various disubstituted 5,6-fused heterocycles using a microwave-assisted one-pot cyclization-Suzuki coupling approach is described. This work highlights the toleran...

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The residue C221 on pyruvate decarboxylase (EC. 4.1.1.1) from Saccharomyces cerevisiae has been shown to be the site where the substrate activation cascade is triggered [Baburina et al. (1994) Biochem...

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More Articles

Related Compounds

  • 1-Bromo-4-phenyl-2-butanone
  • 1-Bromo-3-methyl-2-butanone
  • 1-Bromo-4-(4-methoxyphenyl)-2-butanone
  • 1-bromo-3-hydroxy-3-methyl-2-butanone
  • 1-bromo-4-[p-(carbomethoxy)phenoxy]2-butanone
  • 1-bromo-4-[p-(carbomethoxy)phenoxy]-2-butanone oxime
  • 5-Bromo-3-ethoxy-1-(4-methoxybenzyl)-1h-pyrazolo[3,4-b]pyridine
  • (5-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methanol
  • 3,4-Dimethoxy-I+/--methyl-N-(1-methylpentyl)benzeneethanamine
  • 2-Amino-6-phenyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile
  • Benzenepropanamine, 2,4-difluoro-I+/--methyl-N-propyl-
  • 8-Chloro-2,3-dimethylquinolin-4-amine
  • 1H-Pyrazole-1-propanoic acid, 4-iodo-I+/--methyl-, ethyl ester
  • 2-Amino-6-methyl-5,6,7,8-tetrahydroquinoline-3-carbonitrile
  • 3-(2-(Bromomethyl)-3-methylbutyl)thiophene
  • 2-[2-(Bromomethyl)butyl]-5-chlorothiophene
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