Atomoxetine Hydrochloride

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Names

[ CAS No. ]:
82248-59-7

[ Name ]:
Atomoxetine Hydrochloride

[Synonym ]:
Atomoxetine HCL
benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride
(gR)-N-Methyl-g-(2-methylphenoxy)benzenepropanamine Hydrochloride
(3R)-N-méthyl-3-(2-méthylphénoxy)-3-phénylpropan-1-amine chlorhydrate
MFCD06410992
(3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride (1:1)
Atomoxetine hydrochloride
EINECS 200-659-6
(3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride
(3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-aminhydrochlorid
(3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine hydrochloride (1:1)
Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride (1:1)
Atomoxetine (hydrochloride)

Chemical & Physical Properties

[ Boiling Point ]:
389ºC at 760 mmHg

[ Melting Point ]:
167-169ºC

[ Molecular Formula ]:
C17H22ClNO

[ Molecular Weight ]:
291.816

[ Flash Point ]:
164.1ºC

[ Exact Mass ]:
291.138977

[ PSA ]:
21.26000

[ LogP ]:
4.91750

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK Germany ]:
3

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Iodotoluene
  • ( R)-3-(Methylamino)-1-phenylpropanol
  • (R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropylamine
  • (R)-tomoxetine (S)-(+)- mandelic acid salt
  • (R)-atomoxetine oxalate
  • (-)-N-tert-butoxycarbonyl-N-methyl-3-phenyl-3-(2-methylphenoxy)propanamine
  • o-cresol
  • methylamine
  • (R)-3-Chloro-1-phenyl-1-(2-methylphenoxy)propane

DownStream

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats.

J. Neurosci. 35(1) , 161-9, (2015)

Positive social interactions during the juvenile and adolescent phases of life, in the form of social play behavior, are important for social and cognitive development. However, the neural mechanisms ...

Atomoxetine prevents dexamethasone-induced skeletal muscle atrophy in mice.

J. Pharmacol. Exp. Ther. 351(3) , 663-73, (2014)

Skeletal muscle atrophy remains a clinical problem in numerous pathologic conditions. β2-Adrenergic receptor agonists, such as formoterol, can induce mitochondrial biogenesis (MB) to prevent such atro...

Current pharmacotherapy of attention deficit hyperactivity disorder.

Drugs Today (Barc) 49(10) , 647-65, (2013)

Attention deficit hyperactivity disorder (ADHD) is a neurobehavioral developmental disorder in children and adults characterized by a persistent pattern of impulsiveness, inattention and hyperactivity...


More Articles

Related Compounds

  • rac Atomoxetine Hydrochloride
  • m-Methyl Atomoxetine Hydrochloride
  • p-Methyl Atomoxetine Hydrochloride
  • Desmethyl Atomoxetine Hydrochloride
  • Desmethyl Atomoxetine Hydrochloride
  • ent S-(+)-Atomoxetine Hydrochloride
  • 3-{2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl}pyrazine-2-carbonitrile
  • N,N-dimethyl-6-{2-thia-5-azabicyclo[2.2.1]heptane-5-carbonyl}pyridazin-3-amine
  • 5-[(1-methyl-1H-pyrazol-4-yl)sulfonyl]-2-thia-5-azabicyclo[2.2.1]heptane
  • 1-(1,3-dimethyl-1H-pyrazole-5-carbonyl)-4-{9-methyl-7H,8H,9H,10H-pyrazino[1,2-b]indazol-1-yl}piperazine
  • N-{1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}-1-(5,6,7,8-tetrahydroquinazolin-4-yl)piperidin-4-amine
  • N-{[3-(1-methyl-1H-pyrazol-4-yl)-1,2,4-oxadiazol-5-yl]methyl}morpholine-4-sulfonamide
  • 2-Methyl-4-[4-(2-methylpyrimidin-4-yl)piperazin-1-yl]-6-(trifluoromethyl)pyrimidine
  • 4-[4-(5-Bromothiophene-2-carbonyl)piperazin-1-yl]-2-methyl-6-(trifluoromethyl)pyrimidine
  • 6-cyclobutyl-N-{1-[6-(trifluoromethyl)pyrimidin-4-yl]piperidin-4-yl}pyrimidin-4-amine
  • 4-{4-[1-(4-Fluorophenyl)cyclopropanecarbonyl]piperazin-1-yl}-6-(trifluoromethyl)pyrimidine
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