Ganciclovir

Suppliers

Names

[ Name ]:
Ganciclovir

[Synonym ]:
6H-Purin-6-one, 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-
Vitrasert
Gancyclovir
HHEMG
T56 BN DN FN HNJ D1OY1Q1Q GZ IQ
MFCD00870588
Ganciclovir
Cymevene
bwb759u
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,9-dihydro-6H-purin-6-one
2'-ndg
6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-
DHPG
biolf62
T56 BN DN FVM INJ B1OY1Q1Q HZ
cymevan
Cytovene
1,3-Propanediol, 2-[(2,3-dihydro-6-hydroxy-2-imino-9H-purin-9-yl)methoxy]-
2-Amino-9-{[(1,3-dihydroxy-2-propanyl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
BW B759U
bw-759u
GVC
2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1,9-dihydro-6H-purin-6-one
2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one
2-[(6-Hydroxy-2-imino-2,3-dihydro-9H-purin-9-yl)methoxy]-1,3-propanediol
bw-759

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
657.0±65.0 °C at 760 mmHg

[ Melting Point ]:
250°C

[ Molecular Formula ]:
C₉H₁₃N₅O₄

[ Molecular Weight ]:
255.231

[ Flash Point ]:
351.1±34.3 °C

[ Exact Mass ]:
255.096756

[ PSA ]:
139.28000

[ LogP ]:
-3.62

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.761

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
0.1 M HCl: 10 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF8407000

CHEMICAL NAME :: Guanine, 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-

CAS REGISTRY NUMBER :: 82410-32-0

LAST UPDATED :: 199109

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H13-N5-O4

MOLECULAR WEIGHT :: 255.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 38,281,1986

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360

[ Precautionary Statements ]:
P201-P280-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R46;R60;R61

[ Safety Phrases ]:
S53-S36/37/39-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MF8407000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Triacetyl-ganciclovir
9-[[2-(benzyloxy)-1-[(benzyloxy)methyl]ethoxy]methyl]guanine
2-(2-amino-1,6-dihydro-6-oxopurin-9-yl)methoxy-1,3-bis-1'-propyl-(2'S)-azido-3'-methylbutanoate
Guanine
1,1'-[[2-(Chloromethoxy)-1,3-propanediyl]bis(oxymethylene)]bisbenzene
ganciclovir
N2-acetyl-9-[[1,3-bis(benzyloxy)-2-propoxy]methyl]guanine
2,6,9-tris(trimethylsilyl)guanine
N2-acetyl-9-((1,3-pivaloyloxy-2-propoxy)methyl)guanine

DownStream

Ganciclovir Mono-O-propionate
Valganciclovir
Valganciclovir Hydrochloride
3,9-dihydro-3-((1,3-dihydroxy-2-propoxy)methyl)-6-methyl-9-oxo-5H-imidazol(1,2-a)purine
CBZ-valganciclovir
(2S,2'S)-2-((2-amino-6-oxo-1H-purin-9(6H)-yl)methoxy)propane-1,3-diyl bis(2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate)
2-[(2,6-diaminopurin-9-yl)methoxy]propane-1,3-diol
2-[(2-aminopurin-9-yl)methoxy]propane-1,3-diol

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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