Oxygen-fluorine acid

Suppliers

Names

[ Name ]:
Oxygen-fluorine acid

[Synonym ]:
7H-1,4-Oxazino[2,3,4-ij]quinoline-6-carboxylic acid, 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-
MFCD00226106
UNII:501W86694Z
9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
Oxygen-fluorine acid

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
459.2±45.0 °C at 760 mmHg

[ Melting Point ]:
320-322ºC(lit.)

[ Molecular Formula ]:
C₁₃H₉F₂NO₄

[ Molecular Weight ]:
281.212

[ Flash Point ]:
231.5±28.7 °C

[ Exact Mass ]:
281.049957

[ PSA ]:
68.53000

[ LogP ]:
0.99

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.636

[ Storage condition ]:
-20?C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Tetrabutylammonium fluoride
ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate
diethyl [(-)-7,8-difluoro-3-methyl-2,3-dihydro-4H-[1,4]benzoxazin-4-yl]methylenemalonate
6-amino-2,3-difluorophenol
diethyl N-(3,4-difluoro-2-hydroxyphenyl)aminomethylenemalonate
Tert-butyln-(3,4-difluorophenyl)carbamate
diethyl [3,4-difluoro-2-(2-hydroxypropyloxy)anilinyl]methylenemalonate
2,3,4-Trifluoronitrobenzene
2-Acetonyloxy-3,4-difluoro nitrobenzene

DownStream

Ofloxacin
Ofloxacin impurity E
4-n-Propyl ofloxacin

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2.

J. Med. Chem. 49 , 6443-50, (2006)

Due to the emerging role of protein kinase CK2 as a molecule that participates not only in the development of some cancers but also in viral infections and inflammatory failures, small organic inhibit...

Effect of N-1/c-8 ring fusion and C-7 ring structure on fluoroquinolone lethality.

Antimicrob. Agents Chemother. 54 , 5214-21, (2010)

Quinolones rapidly kill bacteria by two mechanisms, one that requires protein synthesis and one that does not. The latter, which is measured as lethal action in the presence of the protein synthesis i...

On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. Amori L, et al.

J. Neurochem. 109(2) , 316-325, (2009)

oxygen(2-),uranium,dibenzoate
oxygen-evolving complex, 23 kDa precursor
Alizarin fluorine blue-5-sulphonic acid
5-fluorine-2-((4-Methylpiperazin-1-yl)Methyl)phenylboronatehydrochloride
tetrazinc,boric acid,oxygen(2-)
CARBOPHENOTHION OXYGEN ANALOG SULFOXIDE)
1-{4-[(5-Bromopyrimidin-2-yl)oxy]piperidin-1-yl}-2-(2,4-difluorophenyl)ethan-1-one
5-(4-{3-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}piperazin-1-yl)pyridine-2-carbonitrile
1-Methyl-N-(1-thieno[3,2-d]pyrimidin-4-ylazetidin-3-yl)triazole-4-carboxamide
N-{[1-(3,4-dihydro-2H-1-benzopyran-2-carbonyl)piperidin-4-yl]methyl}-3-methoxy-N-methylpyrazin-2-amine
tert-butyl N-(5-hydroxypentan-2-yl)-N-[(4-methoxyphenyl)methyl]carbamate
4-Methoxy-2-{4-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl}pyrimidine
2-[[4-[4-(Trifluoromethyl)pyrimidin-2-yl]oxypiperidin-1-yl]methyl]imidazo[1,2-a]pyridine
1-Methyl-6-oxo-N-(1-thieno[3,2-d]pyrimidin-4-ylazetidin-3-yl)pyridazine-3-carboxamide
2-[(1-{Pyrido[3,4-d]pyrimidin-4-yl}piperidin-4-yl)oxy]-4-(trifluoromethyl)pyrimidine
4-cyclobutyl-6-(4-{1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}piperazin-1-yl)pyrimidine

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.