Flurithromycin

Suppliers

Names

[ Name ]:
Flurithromycin

[Synonym ]:
fluritromicina
Huritromicina(sp)
8-fluoro-erythromyci
cl-932
8-fluoroerythromycin
P-0501-A
C1-932
(8S)-8-fluoroerythromycin A

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
814.6ºC at 760 mmHg

[ Molecular Formula ]:
C₃₇H₆₆FNO₁₃

[ Molecular Weight ]:
751.91700

[ Flash Point ]:
446.5ºC

[ Exact Mass ]:
751.45200

[ PSA ]:
193.91000

[ LogP ]:
1.87770

[ Index of Refraction ]:
1.531

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KF4800000

CHEMICAL NAME :: Erythromycin, 8-fluoro-

CAS REGISTRY NUMBER :: 82664-20-8

LAST UPDATED :: 199310

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C37-H66-F-N-O13

MOLECULAR WEIGHT :: 752.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,214,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,214,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,84-108,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,84-108,1984

Safety Information

[ Hazard Codes ]:
F

[ Risk Phrases ]:
10

[ Safety Phrases ]:
16

Related Compounds

flurithromycin ethylsuccinate
4-Chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxaldehyde
4-Chloro-5-iodo-7-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidine-6-methanol
3-(2-Chloro-5-(trifluoromethyl)pyrimidin-4-yl)-1h-indole-6-carbonitrile
4-Chloro-7-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
1-[4-(3-Bromophenyl)-3,3-dimethyl-1-piperazinyl]ethanone
7-Chloro-3-[2-chloro-5-(trifluoromethyl)-4-pyrimidinyl]-1H-indole-6-carbonitrile
8-Hydroxy-1-methyl-6-morpholinoquinoxalin-2(1H)-one
(4-Isopropoxypyridazin-3-yl)methanol
tert-butyl N-[2-oxo-2-[4-(trifluoromethoxy)phenyl]ethyl]carbamate
tert-butyl N-[2-amino-2-[4-(trifluoromethoxy)phenyl]ethyl]carbamate

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