Flurithromycin

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Names

[ CAS No. ]:
82664-20-8

[ Name ]:
Flurithromycin

[Synonym ]:
fluritromicina
Huritromicina(sp)
8-fluoro-erythromyci
cl-932
8-fluoroerythromycin
P-0501-A
C1-932
(8S)-8-fluoroerythromycin A

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
814.6ºC at 760 mmHg

[ Molecular Formula ]:
C37H66FNO13

[ Molecular Weight ]:
751.91700

[ Flash Point ]:
446.5ºC

[ Exact Mass ]:
751.45200

[ PSA ]:
193.91000

[ LogP ]:
1.87770

[ Index of Refraction ]:
1.531

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KF4800000
CHEMICAL NAME :
Erythromycin, 8-fluoro-
CAS REGISTRY NUMBER :
82664-20-8
LAST UPDATED :
199310
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C37-H66-F-N-O13
MOLECULAR WEIGHT :
752.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,214,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,214,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,84-108,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
790 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,84-108,1984

Safety Information

[ Hazard Codes ]:
F

[ Risk Phrases ]:
10

[ Safety Phrases ]:
16

Related Compounds

  • flurithromycin ethylsuccinate
  • 5-((3AS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(6-oxohexyl)pentanamide
  • 1-Methyl-1,2,5,6-tetrahydropyridine-2-carboxylic acid
  • N-(1,3-Dimethyl-1H-pyrazol-4-yl)-3-pyridinemethanamine
  • N-{[4-(dimethylamino)phenyl]methyl}-1,5-dimethyl-1H-pyrazol-4-amine
  • 1-Ethyl-N-(pyridin-2-ylmethyl)-1H-pyrazol-4-amine
  • 1-Ethyl-N-(pyridin-4-ylmethyl)-1H-pyrazol-4-amine
  • 1-Ethyl-N-(pyridin-3-ylmethyl)-1H-pyrazol-4-amine
  • 1-Ethyl-N-((1-methyl-1H-pyrrol-2-yl)methyl)-1H-pyrazol-4-amine
  • 1-Ethyl-N-[(5-methylfuran-2-yl)methyl]-1H-pyrazol-4-amine
  • 1-ethyl-N-(thiophen-2-ylmethyl)-1H-pyrazol-4-amine
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