Flurithromycin

Suppliers

Names

[ Name ]:
Flurithromycin

[Synonym ]:
fluritromicina
Huritromicina(sp)
8-fluoro-erythromyci
cl-932
8-fluoroerythromycin
P-0501-A
C1-932
(8S)-8-fluoroerythromycin A

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
814.6ºC at 760 mmHg

[ Molecular Formula ]:
C₃₇H₆₆FNO₁₃

[ Molecular Weight ]:
751.91700

[ Flash Point ]:
446.5ºC

[ Exact Mass ]:
751.45200

[ PSA ]:
193.91000

[ LogP ]:
1.87770

[ Index of Refraction ]:
1.531

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KF4800000

CHEMICAL NAME :: Erythromycin, 8-fluoro-

CAS REGISTRY NUMBER :: 82664-20-8

LAST UPDATED :: 199310

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C37-H66-F-N-O13

MOLECULAR WEIGHT :: 752.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,214,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 12,214,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,84-108,1984

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 37,84-108,1984

Safety Information

[ Hazard Codes ]:
F

[ Risk Phrases ]:
10

[ Safety Phrases ]:
16

Related Compounds

flurithromycin ethylsuccinate
{2,2-difluoro-1-[2-(1H-pyrazol-1-yl)ethyl]cyclopropyl}methanamine
2,2-Difluoro-3-(4-hydroxy-2-methoxyphenyl)propanoic acid
2-Azido-2-(2-methyl-5-nitrophenyl)ethan-1-ol
3-Ethynyl-2,4,6-trimethyl-5-sulfanylbenzoic acid
Ethyl 6-chloro-2-ethyl-4-methylnicotinate
(2S)-3-[4-(2,2-dimethylpropanoyloxymethyl)phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
3-(3-Chloro-2,4-difluorophenyl)-1,1-difluoro-2-methylpropan-2-amine
1-[2-Bromo-4-(trifluoromethyl)phenyl]prop-2-en-1-one
rac-(1R,3R)-3-(2-fluoro-4-methylphenyl)-2,2-dimethylcyclopropan-1-amine
1-(2,3-Bis(difluoromethyl)phenyl)-2-bromopropan-1-one

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