Nefazodone hydrochloride

Suppliers

Names

[ CAS No. ]:
82752-99-6

[ Name ]:
Nefazodone hydrochloride

[Synonym ]:
MFCD00865396
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one,hydrochloride
Nefazodone Hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
599.6ºC at 760 mmHg

[ Melting Point ]:
186-188ºC

[ Molecular Formula ]:
C25H33Cl2N5O2

[ Molecular Weight ]:
506.46800

[ Flash Point ]:
316.4ºC

[ Exact Mass ]:
505.20100

[ PSA ]:
55.53000

[ LogP ]:
4.35680

[ Storage condition ]:
Desiccate at RT

[ Water Solubility ]:
DMSO: ~11 mg/mL at 60 °C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • EPT
  • 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride

DownStream

Articles

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

J. Chromatogr. A. 1374 , 122-33, (2014)

The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...

The relation between changes in patients' interpersonal impact messages and outcome in treatment for chronic depression.

J. Consult. Clin. Psychol. 80(3) , 354-64, (2012)

Interpersonal theories posit that chronically depressed individuals have hostile and submissive styles in their social interactions, which may undermine their interpersonal effectiveness and maintain ...

Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug.

Drug Metab. Dispos. 36(6) , 1016-29, (2008)

In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attem...


More Articles

Related Compounds

  • [14C]-Nefazodone hydrochloride
  • Hydroxy Nefazodone-d6 hydrochloride
  • 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride
  • carnitine hydrochloride
  • Losoxantrone hydrochloride [USAN]
  • Triprolidine hydrochloride
  • 1-(2-Chloroethyl)-3-(thiophen-2-yl)-1,4,6,7-tetrahydrothiopyrano[4,3-c]pyrazole
  • 2-(3-(thiophen-2-yl)-6,7-dihydrothiopyrano[4,3-c]pyrazol-1(4H)-yl)ethan-1-amine
  • 1-Methyl-3-(thiophen-3-yl)-1,4,6,7-tetrahydrothiopyrano[4,3-c]pyrazole
  • 1-Ethyl-3-(thiophen-3-yl)-1,4,6,7-tetrahydrothiopyrano[4,3-c]pyrazole
  • 1-Isopropyl-3-(thiophen-3-yl)-1,4,6,7-tetrahydrothiopyrano[4,3-c]pyrazole
  • 1-(Prop-2-yn-1-yl)-3-(thiophen-3-yl)-1,4,6,7-tetrahydrothiopyrano[4,3-c]pyrazole
  • 1-(2-Chloroethyl)-3-(thiophen-3-yl)-1,4,6,7-tetrahydrothiopyrano[4,3-c]pyrazole
  • 2-(3-(thiophen-3-yl)-6,7-dihydrothiopyrano[4,3-c]pyrazol-1(4H)-yl)ethan-1-amine
  • 1-Ethyl-3-(trifluoromethyl)-1,4,6,7-tetrahydrothiopyrano[4,3-c]pyrazole 5,5-dioxide
  • 3-Phenyl-1,4,6,7-tetrahydrothiopyrano[4,3-c]pyrazole 5,5-dioxide
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