p-Trifluoromethoxy phenol

Names

[ CAS No. ]:
828-27-3

[ Name ]:
p-Trifluoromethoxy phenol

[Synonym ]:
Phenol, 4-(trifluoromethoxy)-
p-(Trifluoromethoxy)phenol
QR DOXFFF
EINECS 212-583-0
p-Trifluoromethoxy phenol
α,α,α,4-Tetrafluoroanisole
MFCD00040988
4-(Trifluoromethoxy)phenol

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
187.5±0.0 °C at 760 mmHg

[ Melting Point ]:
17-18°C

[ Molecular Formula ]:
C₇H₅F₃O₂

[ Molecular Weight ]:
178.109

[ Flash Point ]:
86.1±0.0 °C

[ Exact Mass ]:
178.024170

[ PSA ]:
29.46000

[ LogP ]:
2.35

[ Vapour Pressure ]:
0.5±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.462

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S27-S36/37/39

[ RIDADR ]:
2927

[ WGK Germany ]:
2

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29095090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

4-(Trifluoromethoxy)benzamide
tert-Butyl carbamate
N-Boc-3,4-dihydro-2H-pyridine
tert-butyl 4-[4-(trifluoromethoxy)phenoxy]piperidine-1-carboxylate
5-(Trifluoromethoxy)salicylaldehyde
3-Chloro-4-(trifluoromethoxy)phenol
2-Nitro-4-(trifluoromethoxy)phenol
1-(3-bromopropoxy)-4-(trifluoromethoxy)benzene
2-Methoxy-5-(trifluoromethyl)benzaldehyde
Diphenyl oxide

Customs

[ HS Code ]: 2909500000

[ Summary ]:
2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Catalytic asymmetric synthesis of esters from ketenes.

J. Am. Chem. Soc. 127(17) , 6176-7, (2005)

By building on elementary principles of Brønsted acid-base chemistry, a nucleophile-catalyzed method for the asymmetric synthesis of esters from ketenes has been transformed into a much more versatile...