sodium artesunate

Suppliers

Names

[ CAS No. ]:
82864-68-4

[ Name ]:
sodium artesunate

Chemical & Physical Properties

[ Molecular Formula ]:
C19H27NaO8

[ Molecular Weight ]:
406.40300

[ Exact Mass ]:
406.16000

[ PSA ]:
103.35000

[ LogP ]:
1.26770

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EJ9980000
CHEMICAL NAME :
Butanedioic acid, mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano( 4,3-j)-1,2- benzodioxepin-10-yl)ester, sodium salt, (3R-(3-alpha,5a-beta,6-beta,8a-beta,9-alpha,10- alpha,12-beta,12aR*))-
CAS REGISTRY NUMBER :
82864-68-4
LAST UPDATED :
199503
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C19-H27-O8.Na
MOLECULAR WEIGHT :
406.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
438 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CYTPDT Zhongyao Tongbao. Bulletin of Chinese Materia Medica. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3 Volume(issue)/page/year: 13,234,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
520 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine) V.1- 1981- Volume(issue)/page/year: 2,99,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
475 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JTCMEC Journal of Traditional Chinese Medicine (English Edition). (All-China Assoc. of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine) V.1- 1981- Volume(issue)/page/year: 2,99,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
630 mg/kg/14D-I
TOXIC EFFECTS :
Cardiac - EKG changes not diagnostic of specified effects Blood - changes in bone marrow (not otherwise specified) Blood - changes in other cell count (unspecified)
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 1,135,1987 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
5400 ug/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
CYTPDT Zhongyao Tongbao. Bulletin of Chinese Materia Medica. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-13, 1955-88 Suspended 1960-80(?). For Publisher information, see ZZZAE3 Volume(issue)/page/year: 13,234,1988

Related Compounds

  • sodium,(Z)-4-[(2-amino-3-methylbutanoyl)amino]-3-chloro-5-hydroxy-5-oxopent-2-enoate
  • sodium lauroamphoacetate
  • sodium boron(-1) anion
  • sodium [5-chloro-3-[[4,5-dihydro-3-methyl-5-oxo-1-(3-sulphophenyl)-1H-pyrazol-4-yl]azo]-2-hydroxybenzenesulphonato(4-)]chromate(1-)
  • sodium salt of 2-mercapto-4,5-bis-p-chlorophenyl-oxazole
  • sodium 5-chloro-3-[(1,5-dihydroxy-2-naphthyl)azo]-2-hydroxybenzenesulphonate
  • Ethyl I+/--cyano-I-oxobenzenepentanoate
  • 2-(2-Iodophenyl)-1-methylindole
  • 7-Bromoindolo[2,1-b]quinazoline-6,12-dione
  • Ethyl 2-(4-bromo-6-fluoropyridin-2-yl)acetate
  • (2R,3S)-N-Methyl-2-(pyridin-3-yl)tetrahydrofuran-3-amine dihydrochloride
  • N-(3-Cyanophenyl)-2,2,2-trifluoroacetimidoyl chloride
  • Rel-(1R,4R,5S)-1-(1-methyl-1H-pyrazol-5-yl)bicyclo[2.1.1]hexane-5-carboxylic acid
  • Cyclopropyl 4-aminobenzoate
  • Ethyl 3-(2,4-dimethylphenyl)-5-methylisoxazole-4-carboxylate
  • 2-(4-Ethoxyphenyl)pyrrolidine-2-carboxylic acid
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.