Trimetrexate glucuronate

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Names

[ CAS No. ]:
82952-64-5

[ Name ]:
Trimetrexate glucuronate

[Synonym ]:
CI 898 dihydrochloride
CI 898 TRIHYDROCHLORIDE
Trimetrexate glucuronate

Chemical & Physical Properties

[ Density]:
1.305 g/cm3

[ Boiling Point ]:
647ºC at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₃N₅O₁₀

[ Molecular Weight ]:
563.55700

[ Flash Point ]:
345.1ºC

[ Exact Mass ]:
563.22300

[ PSA ]:
244.99000

[ LogP ]:
0.84680

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ8945000

CAS REGISTRY NUMBER :: 82952-64-5

LAST UPDATED :: 199412

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H23-N5-O3.C6-H10-O7

MOLECULAR WEIGHT :: 563.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2027 ug/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Gastrointestinal - other changes Blood - thrombocytopenia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4054 mg/kg/3W-I

TOXIC EFFECTS :: Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg/5D-C

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Blood - changes in platelet count Related to Chronic Data - changes in testicular weight

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 500 nmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 40,1981,1990