4-Aminoantipyrine

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Names

[ CAS No. ]:
83-07-8

[ Name ]:
4-Aminoantipyrine

[Synonym ]:
4-amino-1,5-dimethyl-2-phenylpyrazol-3-one
EINECS 201-452-3
4-Aminoantipyrine
MFCD00003145

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
309.0±45.0 °C at 760 mmHg

[ Melting Point ]:
105-110 °C(lit.)

[ Molecular Formula ]:
C11H13N3O

[ Molecular Weight ]:
203.240

[ Flash Point ]:
140.7±28.7 °C

[ Exact Mass ]:
203.105865

[ PSA ]:
52.95000

[ LogP ]:
-0.40

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. May be light sensitive.

[ Water Solubility ]:
ca. 500 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CD2480000
CHEMICAL NAME :
Antipyrine, 4-amino-
CAS REGISTRY NUMBER :
83-07-8
BEILSTEIN REFERENCE NO. :
0181635
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C11-H13-N3-O
MOLECULAR WEIGHT :
203.27
WISWESSER LINE NOTATION :
T5NNVJ A1 BR& DZ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
270 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

MUTATION DATA

TYPE OF TEST :
DNA repair
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
312 ug/well
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 133,161,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82277 No. of Facilities: 114 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 1130 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82277 No. of Facilities: 1080 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 12808 (estimated) No. of Female Employees: 9012 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
CD2480000

[ HS Code ]:
29331190

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3H-Pyrazol-3-one,1,2-dihydro-1,5-dimethyl-4-nitroso-2-phenyl-
  • Antipyrine
  • aminophenazone
  • 4-[(2,2,2-Trichlor-1,1-dimethylethoxycarbonyl)amino]antipyrin
  • N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)benzamide
  • Metamizole sodium
  • Hydrochloric acid
  • Sulfuric acid
  • 4-Sulfate Aminoantipyrine

DownStream

  • Acetamide,2-chloro-N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-
  • Ramifenazone
  • Nifenazone
  • α-Cumyl alcohol
  • 1,3-BIS-(1,5-DIMETHYL-3-OXO-2-PHENYL-2,3-DIHYDRO-1H-PYRAZOL-4-YL)-THIOUREA
  • N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)thiophene-2-carboxamide
  • 4-Acetamidoantipyrin
  • 5-methyl-2-phenylpyrazole-3,4-dione
  • N-methyl-N-phenyl-acetohydrazide
  • 4-amino-2,4-dihydro-5-methyl-2-phenyl-3H-Pyrazol-3-one

Customs

[ HS Code ]: 2933199090

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Related Compounds

  • 4-AMINOANTIPYRINE-D3
  • 4-AMINOANTIPYRINE HCl
  • N-Formyl-4-aminoantipyrine
  • N-Acetyl-4-aminoantipyrine
  • benzylidene-4-aminoantipyrine
  • p-nitrobenzylidene-4-aminoantipyrine
  • N-(phenylsulfonyl)pyrrolidine-2-carboxamide
  • N-(3-chloro-4-methylphenyl)-2-(3-((4-methylbenzyl)sulfonyl)-1H-indol-1-yl)acetamide
  • N-(tert-butyl)-2-(3-((4-methylbenzyl)sulfonyl)-1H-indol-1-yl)acetamide
  • N-(4-ethylphenyl)-2-(3-((4-methylbenzyl)sulfonyl)-1H-indol-1-yl)acetamide
  • 1-(4-(2-methoxyphenyl)piperazin-1-yl)-2-(3-((4-methylbenzyl)sulfonyl)-1H-indol-1-yl)ethanone
  • N-ethyl-2-(3-((4-methylbenzyl)sulfonyl)-1H-indol-1-yl)-N-phenylacetamide
  • N-(2-methoxyethyl)-2-(3-((4-methylbenzyl)sulfonyl)-1H-indol-1-yl)acetamide
  • N-(2-chlorobenzyl)-2-(3-((4-methylbenzyl)sulfonyl)-1H-indol-1-yl)acetamide
  • N-(4-isopropylphenyl)-2-(3-((4-methylbenzyl)sulfonyl)-1H-indol-1-yl)acetamide
  • 5-Ethyloxolane-3-thiol