musk ambrette
Suppliers
Names
[ CAS No. ]:
83-66-9
[ Name ]:
musk ambrette
[Synonym ]:
5-tert-Butyl-1,3-dinitro-4-methoxy-2-methylbenzene
EINECS 201-493-7
2-tert-butyl-5-methyl-4,6-dinitroanisole
4-tert-Butyl-2,6-dinitro-3-methoxytoluene
6-tert-Butyl-3-methyl-2,4-dinitroanisol
syntheticmuskambrette
2-Methoxy-4-methyl-1-(2-methyl-2-propanyl)-3,5-dinitrobenzene
6-tert-Butyl-3-methyl-2,4-dinitrophenyl methyl ether
AMBRETTEMUSKRESIDUES
1-tert-butyl-2-methoxy-4-methyl-3,5-dinitro-benzene
artificialmuskambrette
Benzene, 1- (1,1-dimethylethyl)-2-methoxy-4-methyl-3,5-dinitro-
MOSCHUS-AMBRETTE
ambermust
Musk amberette
1-tert-Butyl-2-methoxy-4-methyl-3,5-dinitrobenzol
Amber musk
Ambrottolide
6-tert-butyl-3-methyl-2,4-dinitro-anisole
1-tert-butyl-2-methoxy-4-methyl-3,5-dinitrobenzene
6-tert-Butyl-3-methyl-2,4-dinitro-anisol
Benzene, 1-(1,1-dimethylethyl)-2-methoxy-4-methyl-3,5-dinitro-
ambrettemusk
musk ambrette
MFCD00024268
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
369.3±42.0 °C at 760 mmHg
[ Melting Point ]:
84-86°C
[ Molecular Formula ]:
C12H16N2O5
[ Molecular Weight ]:
268.266
[ Flash Point ]:
149.6±29.9 °C
[ Exact Mass ]:
268.105927
[ PSA ]:
100.87000
[ LogP ]:
3.71
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.542
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BZ8575000
- CHEMICAL NAME :
- Anisole, 6-t-butyl-3-methyl-2,4-dinitro-
- CAS REGISTRY NUMBER :
- 83-66-9
- BEILSTEIN REFERENCE NO. :
- 1889437
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C12-H16-N2-O5
- MOLECULAR WEIGHT :
- 268.30
- WISWESSER LINE NOTATION :
- WNR B1 DO1 CNW EX1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 339 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory stimulation Skin and Appendages - hair
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10500 mg/kg/20W-I
- TOXIC EFFECTS :
- Behavioral - muscle weakness Musculoskeletal - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6300 mg/kg/12W-C
- TOXIC EFFECTS :
- Brain and Coverings - demyelination Spinal Cord - demyelination Peripheral Nerve and Sensation - structural change in nerve or sheath
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6750 mg/kg/90D-I
- TOXIC EFFECTS :
- Spinal Cord - demyelination Peripheral Nerve and Sensation - structural change in nerve or sheath Related to Chronic Data - changes in testicular weight
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 10 mmol/L
- REFERENCE :
- FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 21,707,1983 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,477,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,477,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 65,477,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83003 No. of Facilities: 260 (estimated) No. of Industries: 4 No. of Occupations: 20 No. of Employees: 23082 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83003 No. of Facilities: 1567 (estimated) No. of Industries: 11 No. of Occupations: 16 No. of Employees: 22736 (estimated) No. of Female Employees: 16492 (estimated)
Safety Information
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S26-S36/37/39
[ RIDADR ]:
2811
[ RTECS ]:
BZ8575000
[ HS Code ]:
2909309090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2909309090
[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%