5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID

Suppliers

Names

[ CAS No. ]:
83-93-2

[ Name ]:
5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID

[Synonym ]:
Tetrophan
Tetrofan
5,6-dihydrobenz<c>acridine-7-carboxylic acid
3,4-Dihydro-1,2-benzacridinic-5-carbonic acid

Chemical & Physical Properties

[ Density]:
1.336g/cm3

[ Boiling Point ]:
495.8ºC at 760 mmHg

[ Molecular Formula ]:
C18H13NO2

[ Molecular Weight ]:
275.30100

[ Flash Point ]:
253.7ºC

[ Exact Mass ]:
275.09500

[ PSA ]:
50.19000

[ LogP ]:
3.69860

[ Index of Refraction ]:
1.719

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CU3350000
CHEMICAL NAME :
Benz(c)acridine-7-carboxylic acid, 5,6-dihydro-
CAS REGISTRY NUMBER :
83-93-2
BEILSTEIN REFERENCE NO. :
0256492
LAST UPDATED :
199709
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C18-H13-N-O2
MOLECULAR WEIGHT :
275.32
WISWESSER LINE NOTATION :
T D6 C666 BN&T&&J MVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,27,1955
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,27,1955
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Behavioral - tetany Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,371,1955

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • isatin
  • 3,4-Dihydronaphthalen-1(2H)-one

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 5,5-dimethyl-5,6-dihydro-benzo[c]acridine-7-carboxylic acid amide
  • 6-methoxy-5,5-dimethyl-5,6-dihydro-benzo[c]acridine-7-carboxylic acid
  • 6-hydroxy-5,5-dimethyl-5,6-dihydro-benzo[c]acridine-7-carboxylic acid ethylamide
  • 6-bromo-5,5-dimethyl-6H-benzo[c]acridine-7-carboxylic acid
  • 5,5-dimethyl-6H-benzo[c]acridine-7-carboxylic acid
  • methyl 5,6-dimethylbenzo[c]acridine-7-carboxylate