4-(Trifluoromethyl)benzenesulfonamide

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Names

[ CAS No. ]:
830-43-3

[ Name ]:
4-(Trifluoromethyl)benzenesulfonamide

[Synonym ]:
Benzenesulfonamide, 4-(trifluoromethyl)-
MFCD00042421
einecs 212-596-1
4-(Trifluoromethyl)benzenesulphonamide
p-(Trifluoromethyl)benzenesulfonamide
4-(Trifluoromethyl)benzenesulfonamide
Benzenesulfonamide, p-(trifluoromethyl)-
ZSWR DXFFF
α,α,α-Trifluoro-p-toluenesulphonamide

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
304.8±52.0 °C at 760 mmHg

[ Melting Point ]:
175-180 °C(lit.)

[ Molecular Formula ]:
C7H6F3NO2S

[ Molecular Weight ]:
225.188

[ Flash Point ]:
138.1±30.7 °C

[ Exact Mass ]:
225.007126

[ PSA ]:
68.54000

[ LogP ]:
1.24

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.494

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB3200000
CHEMICAL NAME :
Benzenesulfonamide, p-(trifluoromethyl)-
CAS REGISTRY NUMBER :
830-43-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H6-F3-N-O2-S
MOLECULAR WEIGHT :
225.20
WISWESSER LINE NOTATION :
ZSWR DXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
533 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,548,1965

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DB3200000

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(Trifluoromethyl)benzenesulfonyl chloride
  • 4-Aminobenzotrifluoride

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Related Compounds

  • 2-Bromo-4-(trifluoromethyl)benzenesulfonamide
  • 2-Nitro-4-(trifluoromethyl)benzenesulfonamide
  • N-phenyl-4-(trifluoromethyl)benzenesulfonamide
  • 2-Chloro-4-(trifluoromethyl)benzenesulfonamide
  • N-p-tolyl-4-(trifluoromethyl)benzenesulfonamide
  • 2,6-dichloro-4-(trifluoromethyl)benzenesulfonamide
  • N,4-dimethyl-N-[1-(pyridin-2-yl)azetidin-3-yl]thiophene-2-carboxamide
  • N-methyl-N-[1-(pyridin-2-yl)azetidin-3-yl]-2-(pyridin-3-yl)acetamide
  • 6-{5-[2-(Pyridin-4-ylsulfanyl)acetyl]-octahydropyrrolo[3,4-c]pyrrol-2-yl}pyridine-3-carbonitrile
  • 2-Cyclopropyl-4-methyl-6-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbonyl}pyrimidine
  • 2-(4-Chlorophenoxy)-N-[(6-hydroxy-1,4-dithiepan-6-yl)methyl]acetamide
  • 5-fluoro-4-methyl-N-[(pyridin-3-yl)methyl]pyridine-2-carboxamide
  • 1-[4-(3-Pyridin-4-yloxyazetidine-1-carbonyl)piperidin-1-yl]ethanone
  • 5-Fluoro-4-methyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)pyridine-2-carboxamide
  • 5-Fluoro-6-methyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)pyridine-2-carboxamide
  • 2-{3-[(4-bromo-1H-pyrazol-1-yl)methyl]azetidine-1-carbonyl}pyrazine
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