Phenformin (hydrochloride)

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Names

[ CAS No. ]:
834-28-6

[ Name ]:
Phenformin (hydrochloride)

[Synonym ]:
Phenformin hydrochloride
Phenformini Hydrochloride
Insora
meltrol
phenforminhclno.9113
Imidodicarbonimidic diamide, N-(2-phenylethyl)-, hydrochloride (1:1)
Glucopostin
Phenformine HCL
dbi-td
β-PEBG HCl
DBI monohydrochloride
usafvi-6
MFCD00035039
Phenformin HCl
PhenforMin HCl API
UNII-91XC93EU03
EINECS 212-637-3
Insoral
N-(2-Phenylethyl)imidodicarbonimidic diamide hydrochloride (1:1)
N-Phenethylbiguanide hydrochloride
1-(2-Phenylethyl)biguanide hydrochloride
N'-b-Phenethylformamidinyliminourea Hydrochloride
Phenformin (hydrochloride)
1,1-Benzylmethylbiguanide hydrochloride

Chemical & Physical Properties

[ Density]:
1.24 g/cm3

[ Boiling Point ]:
413.7ºC at 760 mmHg

[ Melting Point ]:
175-178ºC

[ Molecular Formula ]:
C₁₀H₁₆ClN₅

[ Molecular Weight ]:
241.721

[ Flash Point ]:
204ºC

[ Exact Mass ]:
241.109421

[ PSA ]:
97.78000

[ LogP ]:
2.72010

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
>=10 g/100 mL at 21 ºC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU2200000

CHEMICAL NAME :: Biguanide, 1-phenethyl-, monohydrochloride

CAS REGISTRY NUMBER :: 834-28-6

LAST UPDATED :: 199706

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H15-N5.Cl-H

MOLECULAR WEIGHT :: 241.76

WISWESSER LINE NOTATION :: MUYZMYUM&M2R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 938 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 407 mg/kg

TOXIC EFFECTS :: Endocrine - hypoglycemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 1 mmol/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
2811.0

[ WGK Germany ]:
3

[ RTECS ]:
DU2200000

[ Hazard Class ]:
6.1

[ HS Code ]:
2942000000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2942000000

Articles

Hydrogen sulfide mitigates hyperglycemic remodeling via liver kinase B1-adenosine monophosphate-activated protein kinase signaling.

Biochim. Biophys. Acta 1843(12) , 2816-26, (2014)

Hyperglycemia (HG) reduces AMPK activation leading to impaired autophagy and matrix accumulation. Hydrogen sulfide (H2S) treatment improves HG-induced renovascular remodeling however, its mechanism re...

Lactic acidosis treatment by nanomole level of spermidine in an animal model.

Regul Toxicol Pharmacol 70(2) , 514-8, (2014)

Lactic acidosis occurs in a number of clinical conditions, e.g. in surgeries, orthotopic liver transplant, and anesthetic agent administration, which has deleterious effects on the patient's survival....

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