Phenformin (hydrochloride)

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Names

[ CAS No. ]:
834-28-6

[ Name ]:
Phenformin (hydrochloride)

[Synonym ]:
Phenformin hydrochloride
Phenformini Hydrochloride
Insora
meltrol
phenforminhclno.9113
Imidodicarbonimidic diamide, N-(2-phenylethyl)-, hydrochloride (1:1)
Glucopostin
Phenformine HCL
dbi-td
β-PEBG HCl
DBI monohydrochloride
usafvi-6
MFCD00035039
Phenformin HCl
PhenforMin HCl API
UNII-91XC93EU03
EINECS 212-637-3
Insoral
N-(2-Phenylethyl)imidodicarbonimidic diamide hydrochloride (1:1)
N-Phenethylbiguanide hydrochloride
1-(2-Phenylethyl)biguanide hydrochloride
N'-b-Phenethylformamidinyliminourea Hydrochloride
Phenformin (hydrochloride)
1,1-Benzylmethylbiguanide hydrochloride

Chemical & Physical Properties

[ Density]:
1.24 g/cm3

[ Boiling Point ]:
413.7ºC at 760 mmHg

[ Melting Point ]:
175-178ºC

[ Molecular Formula ]:
C10H16ClN5

[ Molecular Weight ]:
241.721

[ Flash Point ]:
204ºC

[ Exact Mass ]:
241.109421

[ PSA ]:
97.78000

[ LogP ]:
2.72010

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
>=10 g/100 mL at 21 ºC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DU2200000
CHEMICAL NAME :
Biguanide, 1-phenethyl-, monohydrochloride
CAS REGISTRY NUMBER :
834-28-6
LAST UPDATED :
199706
DATA ITEMS CITED :
10
MOLECULAR FORMULA :
C10-H15-N5.Cl-H
MOLECULAR WEIGHT :
241.76
WISWESSER LINE NOTATION :
MUYZMYUM&M2R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
938 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
17500 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
407 mg/kg
TOXIC EFFECTS :
Endocrine - hypoglycemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
19 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
1 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
2811.0

[ WGK Germany ]:
3

[ RTECS ]:
DU2200000

[ Hazard Class ]:
6.1

[ HS Code ]:
2942000000

Precursor & DownStream

Precursor

DownStream

  • phenformin

Customs

[ HS Code ]: 2942000000

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