Platensimycin

Suppliers

Names

[ Name ]:
Platensimycin

[Synonym ]:
Benzoic acid, 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-
3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-1,2,5,6,7,8,9,9a-octahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid
Platensimycin
3-({3-[(1S,5S,6R,7S,9S,10S)-5,9-Dimethyl-4-oxo-8-oxatetracyclo[7.2.1.1.0]tridec-2-en-5-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
683.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₇NO₇

[ Molecular Weight ]:
441.474

[ Flash Point ]:
366.9±31.5 °C

[ Exact Mass ]:
441.178741

[ PSA ]:
136.65000

[ LogP ]:
3.00

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.670

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.

Antimicrob. Agents Chemother. 59(2) , 849-58, (2015)

Delineating the mechanisms for genetically acquired antibiotic resistance is a robust approach to target validation and anticipates the evolution of clinical drug resistance. This study defines a spec...

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.

J. Cell Biol. 203(6) , 985-1001, (2013)

Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response to fatt...

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.

Proc. Natl. Acad. Sci. U. S. A. 108 , 5378-5383, (2011)

Platensimycin (PTM) is a recently discovered broad-spectrum antibiotic produced by Streptomyces platensis. It acts by selectively inhibiting the elongation-condensing enzyme FabF of the fatty acid bio...