Lisinopril diydrate

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Names

[ Name ]:
Lisinopril diydrate

[Synonym ]:
L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-, hydrate (1:2)
(S)-1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate
N-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline dihydrate
MFCD08064198
Lisinopril Dihydrate
EINECS 278-488-1
Lisinopril diydrate
Lisinopril (dihydrate)

Chemical & Physical Properties

[ Density]:
1.251 g/cm3

[ Boiling Point ]:
666.4ºC at 760 mmHg

[ Melting Point ]:
160ºC (Decomposes)

[ Molecular Formula ]:
C₂₁H₃₅N₃O₇

[ Molecular Weight ]:
441.52

[ Flash Point ]:
356.9ºC

[ PSA ]:
132.96000

[ LogP ]:
2.26430

[ Index of Refraction ]:
-45 ° (C=1, 0.25mol/L Zinc Acetate Buffer)

[ Storage condition ]:
2-8°C

[ Stability ]:
Hygroscopic

[ Water Solubility ]:
H2O: ≥10 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TW3589990

CHEMICAL NAME :: L-Proline, 1-(N(sup 2)-(1-carboxy-3-phenylpropyl)-L-lysyl)-, dihydrate, (S)-

CAS REGISTRY NUMBER :: 83915-83-7

LAST UPDATED :: 199507

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H31-N3-O5.2H2-O

MOLECULAR WEIGHT :: 441.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3600 mg/kg

SEX/DURATION :: female 6-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 21,2093,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2800 mg/kg

SEX/DURATION :: female 15-21 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 21,2093,1993

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi,Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
TW3589990

[ WGK Germany ]:
3

[ RTECS ]:
TW3589990

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Isolation and characterization of a novel angiotensin-converting enzyme-inhibitory tripeptide from enzymatic hydrolysis of soft-shelled turtle (Pelodiscus sinensis) egg white: in vitro, in vivo, and in silico study.

J. Agric. Food Chem. 62(50) , 12178-85, (2014)

In this study, a novel angiotensin-converting enzyme (ACE)-inhibitory tripeptide (IVR) was isolated and identified from unfertilized soft-shelled turtle egg white (SSTEW). The IC50 value of IVR was me...

Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial.

JAMA 310(9) , 918-29, (2013)

Most patients with cardiovascular disease (CVD) do not take recommended medications long-term. The use of fixed-dose combinations (FDCs) improves adherence in several clinical areas. Previous trials o...

Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension.

Clin. Sci. 127(1) , 57-63, (2014)

The somatic isozyme of ACE (angiotensin I-converting enzyme) comprises two distinct zinc-dependent catalytic domains with different substrate specificities for angiotensin I (cleaved selectively by th...

Lisinopril (8R,S)-Diketopiperazine (Mixture of Diastereomers)
(2S)-1-[(2S)-6-amino-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
Lisinopril
Lisinopril-d5
Lisinopril ester
Lisinopril Cyclohexyl Analog
2-butyl-5-hydroxy-1H-imidazole-4-carbonitrile
1-(2-methoxy-3-methylbutyl)-1H-1,2,4-triazol-3-amine
5-Amino-1-(2-methoxy-3-methylbutyl)-1,2-dihydropyridin-2-one
1-(3-amino-1H-1,2,4-triazol-1-yl)-3-(dimethylamino)propan-2-ol
2-(4-amino-5-methyl-1H-pyrazol-1-yl)-N-tert-butylacetamide
3-methyl-1-[2-(thiophen-3-yl)ethyl]-1H-pyrazol-4-amine
2-(4-amino-3-methyl-1H-pyrazol-1-yl)-N-cyclopropylpropanamide
2-(Cyclopropylmethyl)-4-phenylfuran-3-carboxylic acid
4-(4-Bromophenyl)-2-[(2,2-dimethylpropanamido)methyl]-4-methylpentanoic acid
2-{[(benzyloxy)carbonyl]amino}-3-(1H-pyrazol-1-yl)butanoic acid

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