Trimeprazine
Suppliers
Names
[ CAS No. ]:
84-96-8
[ Name ]:
Trimeprazine
[Synonym ]:
Methylpromazine
Isobutrazine
EINECS 201-577-3
Repetin
Alimemazine
N,N-dimethyl-N-<2-methyl-3-(10H-10-phenothiazinyl)propyl>amine
Alimezine
dl-Trimeprazine
Teralen
10-[3-(dimethylamino)-2-methylpropyl]phenothiazine
Trimeprazine
Chemical & Physical Properties
[ Density]:
1.203 g/cm3
[ Boiling Point ]:
420.3ºC at 760mmHg
[ Melting Point ]:
68°C
[ Molecular Formula ]:
C18H22N2S
[ Molecular Weight ]:
298.44600
[ Flash Point ]:
208ºC
[ Exact Mass ]:
298.15000
[ PSA ]:
31.78000
[ LogP ]:
4.55200
[ Water Solubility ]:
0.942 mg/L
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO5700000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-
- CAS REGISTRY NUMBER :
- 84-96-8
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C18-H22-N2-S
- MOLECULAR WEIGHT :
- 298.48
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B1Y1&1N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- REFERENCE :
- DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4969 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 333 (estimated) No. of Female Employees: 227 (estimated)
Safety Information
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
[ Safety Phrases ]:
S22:Do not breathe dust . S24/25:Avoid contact with skin and eyes . S36:Wear suitable protective clothing . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
[ RIDADR ]:
2811
[ WGK Germany ]:
3
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)