1'-(2-hydroxy-2-phenylethyl)spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one

Names

[ CAS No. ]:
84060-24-2

[ Name ]:
1'-(2-hydroxy-2-phenylethyl)spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
488.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₂N₂O₃

[ Molecular Weight ]:
338.40000

[ Flash Point ]:
249.1ºC

[ Exact Mass ]:
338.16300

[ PSA ]:
65.29000

[ LogP ]:
2.66050

[ Index of Refraction ]:
1.659

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WH0080000

CHEMICAL NAME :: Spiro(4H-3,1-benzoxazine-4,4'-piperidin)-2(1H)-one, 1'-(2-hydroxy-2-phenylethyl)-

CAS REGISTRY NUMBER :: 84060-24-2

LAST UPDATED :: 199606

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H22-N2-O3

MOLECULAR WEIGHT :: 338.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0070171

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1'-(2-oxo-2-phenylethyl)spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
N-Benzyl-4-piperidone
4-Chloropivalanilide
1-benzyl-4-hydroxy-4-(2-pivaloylamino-5-chlorophenyl)piperidine
4-(2-amino-5-chlorophenyl)-1-benzylpiperidin-4-ol
Spiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one hydrochloride

DownStream