N-Benzhydrylpiperazine

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Names

[ CAS No. ]:
841-77-0

[ Name ]:
N-Benzhydrylpiperazine

[Synonym ]:
Piperazine, 1-(diphenylmethyl)-
EINECS 212-667-7
N-Benzhydrylpiperazine
1-benzhydrylpiperazine
MFCD00038379
Piperazine, 1- (diphenylmethyl)-
1-(Diphenylmethyl)piperazine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
365.1±32.0 °C at 760 mmHg

[ Melting Point ]:
90-93 °C

[ Molecular Formula ]:
C17H20N2

[ Molecular Weight ]:
252.354

[ Flash Point ]:
140.5±16.1 °C

[ Exact Mass ]:
252.162643

[ PSA ]:
15.27000

[ LogP ]:
2.85

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.584

[ Water Solubility ]:
0.45 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL6465000
CHEMICAL NAME :
Piperazine, 1-(diphenylmethyl)-
CAS REGISTRY NUMBER :
841-77-0
BEILSTEIN REFERENCE NO. :
0222773
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C17-H20-N2
MOLECULAR WEIGHT :
252.39
WISWESSER LINE NOTATION :
T6M DNTJ DYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),28,1997
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 31,453,1972

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TL6465000

[ Packaging Group ]:
I; II; III

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • piperazine dihydrochloride
  • benzhydryl chloride
  • Piperazine
  • 1-benzhydryl-4-(ethoxycarbonyl)piperazine
  • Bromodiphenylmethane
  • Benzophenone
  • Benzhydrol
  • formylpiperazine
  • Benzaldehyde
  • Cyclizine

DownStream

  • 1-benzhydryl-4-[(E)-3-(2,3,4-trimethoxyphenyl)prop-2-enyl]piperazine,dihydrochloride
  • N-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-N,4,6-trimethyl-5-nitropyridin-2-amine,trihydrochloride
  • 4-[2-(4-benzhydrylpiperazin-1-yl)ethylimino]-1-hydroxy-2,6-dimethylpyridine-3-carbonitrile,trihydrochloride
  • 2-(4-benzhydrylpiperazin-1-yl)ethanol
  • 1-[bis(4-fluorophenyl)methyl]-4-[3-(2,4-dimethoxyphenyl)prop-2-enyl]piperazine,but-2-enedioic acid
  • Decloxizine
  • Oxatomide
  • NP118809
  • Manidipine
  • 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(9-10) , 605-9, (2011)

A rapid and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed and validated for quantification of cyclizine and its main metabolite norcyclizine in human plasma. Sam...

Oxidative metabolism of cinnarizine in rat liver microsomes.

Biochem. Pharmacol. 44(7) , 1471-4, (1992)

The oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] to 1-(diphenylmethyl)piperazine (M-1), 1-(diphenylmethyl)-4-[3-(4'-hydroxyphenyl)-2-propenyl]pipera...

The reactions of polyhalogenated-2-nitro-1, 3-butadiene with alkylthio, thiomorpholine and piperazine derivatives. Ibis C and Deniz NG.

Indian J. Chem. B 47(9) , 1407, (2008)


More Articles

Related Compounds

  • N-allyl-N-benzhydrylpiperazine dihydrochloride
  • N-allyl-N-benzhydrylpiperazine dihydrochloride
  • N-[4-(4-benzhydrylpiperazine-1-carbonyl)phenyl]-5-chlorothiophene-2-sulfonamide
  • N-hydroxyquinoline-8-sulfonamide
  • N,N-DIMETHYLPYRROLIDIN-3-AMINE HYDROCHLORIDE
  • N-(4-chloro-3-nitrophenyl)quinoline-8-sulfonamide
  • (E)-2-cyano-2-(5-(4-methoxybenzyl)-3-(2-methoxyphenyl)-4-oxothiazolidin-2-ylidene)-N-methylacetamide
  • (E)-2-cyano-2-(5-(4-methoxybenzyl)-3-(naphthalen-1-yl)-4-oxothiazolidin-2-ylidene)-N-methylacetamide
  • 1H-Pyrido[2,1-b]benzothiazole-2,4-dicarbonitrile, 3-[5-[2-chloro-5-(trifluoromethyl)phenyl]-1-methyl-1H-pyrrol-2-yl]-1-oxo-
  • 2-(2-Methoxybenzyl)-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid
  • 3-(2-((6,7-dimethoxyisoquinolin-1-yl)methyl)-4,5-dimethoxyphenyl)isobenzofuran-1(3H)-one
  • 1-(3-chloro-2-methylphenyl)-5-methyl-N-propyl-1H-1,2,3-triazole-4-carboxamide
  • 1-(2,6-dimethylphenyl)-5-methyl-N-((tetrahydrofuran-2-yl)methyl)-1H-1,2,3-triazole-4-carboxamide
  • 1-(3-chloro-2-methylphenyl)-5-methyl-N-((tetrahydrofuran-2-yl)methyl)-1H-1,2,3-triazole-4-carboxamide
  • N-(2,5-dimethoxyphenyl)-1-(2-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide
  • 1-(3-chloro-2-methylphenyl)-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N,5-dimethyl-1H-1,2,3-triazole-4-carboxamide
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