5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimeth ylamino)-4-methoxy-, dihydrochloride

Suppliers

Names

[ CAS No. ]:
84332-26-3

[ Name ]:
5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimeth ylamino)-4-methoxy-, dihydrochloride

[Synonym ]:
N-[(1-benzylpyrrolidin-2-yl)methyl]-2-(dimethylamino)-4-methoxypyrimidine-5-carboxamide dihydrochloride
5-Pyrimidinecarboxamide,N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-,dihydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
603.7ºC at 760 mmHg

[ Molecular Formula ]:
C20H29Cl2N5O2

[ Molecular Weight ]:
442.38300

[ Flash Point ]:
318.9ºC

[ Exact Mass ]:
441.17000

[ PSA ]:
74.08000

[ LogP ]:
4.06230

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV7707200
CHEMICAL NAME :
5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino) -4-methoxy-, dihydrochloride
CAS REGISTRY NUMBER :
84332-26-3
LAST UPDATED :
198609
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H27-N5-O2.2Cl-H
MOLECULAR WEIGHT :
442.44
WISWESSER LINE NOTATION :
T6N CNJ BN1&1 DO1 EVM1- BT5NTJ A1R &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 17,437,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 4-chloro-2-(dimethylamino)pyrimidine-5-carboxylate
  • methyl 2-(dimethylamino)-4-methoxypyrimidine-5-carboxylate
  • ethyl 2-dimethylamino-4-oxo-3H-pyrimidine-5-carboxylate
  • Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate
  • (1-benzylpyrrolidin-2-yl)methanamine
  • 2-(dimethylamino)-4-methoxy-5-pyrimidinyl carboxylic acid

DownStream

Related Compounds

  • 2-(2-Bromopropyl)naphthalene
  • 1-(3-Methylthiophen-2-yl)pentane-1,3-dione
  • 5-(2,2-Difluoro-1-methylcyclopropyl)isoxazol-3-amine
  • CID 62868375
  • 1-(3-Bromobutyl)-4-(trifluoromethyl)benzene
  • 5-bromo-4-methyl-N-tritylpyridin-2-amine
  • 1-(2-Bromopropyl)-2-methylbenzene
  • Methyl 5-cyano-2-phenyl-4-pyridineacetate
  • 5-(1-(Difluoromethyl)cyclopropyl)isoxazol-3-amine
  • 3-(4,4-Dimethyl-2,5-dioxoimidazolidin-1-yl)-2-hydroxy-2-methylpropanoic acid