5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimeth ylamino)-4-methoxy-, dihydrochloride

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Names

[ CAS No. ]:
84332-26-3

[ Name ]:
5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimeth ylamino)-4-methoxy-, dihydrochloride

[Synonym ]:
N-[(1-benzylpyrrolidin-2-yl)methyl]-2-(dimethylamino)-4-methoxypyrimidine-5-carboxamide dihydrochloride
5-Pyrimidinecarboxamide,N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino)-4-methoxy-,dihydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
603.7ºC at 760 mmHg

[ Molecular Formula ]:
C20H29Cl2N5O2

[ Molecular Weight ]:
442.38300

[ Flash Point ]:
318.9ºC

[ Exact Mass ]:
441.17000

[ PSA ]:
74.08000

[ LogP ]:
4.06230

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV7707200
CHEMICAL NAME :
5-Pyrimidinecarboxamide, N-((1-benzyl-2-pyrrolidinyl)methyl)-2-(dimethylamino) -4-methoxy-, dihydrochloride
CAS REGISTRY NUMBER :
84332-26-3
LAST UPDATED :
198609
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H27-N5-O2.2Cl-H
MOLECULAR WEIGHT :
442.44
WISWESSER LINE NOTATION :
T6N CNJ BN1&1 DO1 EVM1- BT5NTJ A1R &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 17,437,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 4-chloro-2-(dimethylamino)pyrimidine-5-carboxylate
  • methyl 2-(dimethylamino)-4-methoxypyrimidine-5-carboxylate
  • ethyl 2-dimethylamino-4-oxo-3H-pyrimidine-5-carboxylate
  • Ethyl 4-hydroxy-2-methylthio-5-pyrimidinecarboxylate
  • (1-benzylpyrrolidin-2-yl)methanamine
  • 2-(dimethylamino)-4-methoxy-5-pyrimidinyl carboxylic acid

DownStream

Related Compounds

  • (2-((difluoromethyl)sulfonyl)phenyl)(4-(1-ethyl-1H-imidazol-2-yl)piperazin-1-yl)methanone hydrochloride
  • cyclopropyl(4-(1-(p-tolyl)-1H-imidazol-2-yl)piperazin-1-yl)methanone hydrochloride
  • ethyl 2-oxo-2-(4-(1-(p-tolyl)-1H-imidazol-2-yl)piperazin-1-yl)acetate hydrochloride
  • (2-chloro-6-fluorophenyl)(4-(1-(p-tolyl)-1H-imidazol-2-yl)piperazin-1-yl)methanone hydrochloride
  • naphthalen-2-yl(4-(1-(p-tolyl)-1H-imidazol-2-yl)piperazin-1-yl)methanone hydrochloride
  • (Z)-3-phenyl-1-(4-(1-(p-tolyl)-1H-imidazol-2-yl)piperazin-1-yl)prop-2-en-1-one hydrochloride
  • 2-phenoxy-1-(4-(1-(p-tolyl)-1H-imidazol-2-yl)piperazin-1-yl)ethanone hydrochloride
  • 4-phenyl-1-(4-(1-(p-tolyl)-1H-imidazol-2-yl)piperazin-1-yl)butan-1-one hydrochloride
  • 3-(4-methoxyphenyl)-1-(4-(1-(p-tolyl)-1H-imidazol-2-yl)piperazin-1-yl)propan-1-one hydrochloride
  • (4-(1-(2-fluorophenyl)-1H-imidazol-2-yl)piperazin-1-yl)(phenyl)methanone hydrochloride
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