N-t-BOC-4-Methylene-L-proline

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Names

[ CAS No. ]:
84348-38-9

[ Name ]:
N-t-BOC-4-Methylene-L-proline

[Synonym ]:
(2S)-4-methylidene-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
(S)-4-METHYLENE-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
MFCD01861787
1-(tert-Butoxycarbonyl)-4-methylene-L-proline
1,2-Pyrrolidinedicarboxylic acid, 4-methylene-, 1-(1,1-dimethylethyl) ester, (2S)-
4-Methylene-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline
N-t-BOC-4-Methylene-L-proline
(S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
349.9±42.0 °C at 760 mmHg

[ Melting Point ]:
110-114ºC

[ Molecular Formula ]:
C11H17NO4

[ Molecular Weight ]:
227.257

[ Flash Point ]:
165.4±27.9 °C

[ Exact Mass ]:
227.115753

[ PSA ]:
66.84000

[ LogP ]:
1.02

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.513

[ Water Solubility ]:
Insoluble in water.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methyltriphenylphosphonium bromide
  • N-Boc-4-oxo-L-proline
  • (S)-1-tert-Butyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate
  • N-phenylsulphonyl-4-exomethylene-(S)-proline benzylester
  • Di-tert-butyl dicarbonate
  • Boc-L-Proline
  • methyl triphenylphosphonium bromide

DownStream

  • (4S)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline
  • (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid
  • (S)-5-tert-butyl 6-methyl 5-azaspiro[2.4]heptane-5,6-dicarboxylate
  • (S)-1-tert-Butyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate
  • L-Proline, 4-methylene-, methyl ester (9CI)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-t-BOC-4-Methylene-L-proline
  • N-t-BOC-4,4-Difluoro-L-proline methyl ester
  • N-t-BOC-4,4-Difluoro-L-Proline
  • N-T-BOC-L-PROLINE-N-HYDROXYSUCCINIMIDE ESTER
  • BOC-4-HYDROXY-5-OXO-L-PROLINE METHYL ESTER
  • ditert-butyl (2S)-4-oxopyrrolidine-1,2-dicarboxylate
  • 2-Methyl-2-azaspiro[3.5]nonan-7-amine
  • Methyl 2-amino-4-bromo-5-fluoro-3-nitrobenzoate
  • tert-Butyl 4-chloro-7-methyl-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate
  • (5R,6R)-6-((R)-1-((tert-Butyldimethylsilyl)oxy)-5-((4-methoxybenzyl)oxy)pent-3-yn-1-yl)-2,2,3,3,12,12,13,13-octamethyl-5-vinyl-4,7,11-trioxa-3,12-disilatetradecane
  • 4,4,5,5-Tetramethyl-2-(3-methyl-7-(trifluoromethyl)-2,3-dihydrobenzofuran-5-yl)-1,3,2-dioxaborolane
  • 2-(4-Amino-2-((tert-butoxycarbonyl)amino)pyrimidin-5-yl)ethyl methanesulfonate
  • 5-[(3S,4S)-4-Cyclopropylpyrrolidin-3-yl]-3-propan-2-yl-1H-1,2,4-triazole;dihydrochloride
  • Methyl 2-cyclopropyl-3-(4-methoxyphenyl)propanoate
  • 3-(3-Hydroxycyclobutyl)propiolic acid
  • tert-Butyl 5-(3-chloro-4-(methoxycarbonyl)phenyl)-1,4-diazepane-1-carboxylate
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