ICI 162,846

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Names

[ CAS No. ]:
84545-30-2

[ Name ]:
ICI 162,846

[Synonym ]:
Tocris-0833

Chemical & Physical Properties

[ Density]:
1.45g/cm3

[ Boiling Point ]:
500.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₁H₁₇F₃N₆O

[ Molecular Weight ]:
306.29

[ Flash Point ]:
256.5ºC

[ Exact Mass ]:
306.14200

[ PSA ]:
108.82000

[ LogP ]:
2.30120

[ Index of Refraction ]:
1.563

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ7889000

CHEMICAL NAME :: 1H-Pyrazole-1-pentanamide, 3-((imino((2,2,2-trifluoroethyl)amino)methyl)amino)-

CAS REGISTRY NUMBER :: 84545-30-2

LAST UPDATED :: 199507

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H17-F3-N6-O

MOLECULAR WEIGHT :: 306.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 365 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 15,366,1987

Related Compounds

ICI 89406
2-(3,4-dichlorophenyl)-N-[1-(3,4-dimethoxyphenyl)-2-pyrrolidin-1-ylethyl]-N-methylacetamide,hydrochloride
ICI 69322
2-(3,4-dichlorophenyl)-N-methyl-N-[(2S)-3-methyl-1-pyrrolidin-1-ylbutan-2-yl]acetamide,hydrochloride
ICI 192605
ici 174,864