Rocaglamide

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Names

[ CAS No. ]:
84573-16-0

[ Name ]:
Rocaglamide

[Synonym ]:
Rocaglamide
(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
1H-Cyclopenta(b)benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-
(1R,2R,3S,3aR,8bS)-1,8b-Dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-2-carboxamide
1H-Benzo[b]cyclopenta[d]furan-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
667.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H31NO7

[ Molecular Weight ]:
505.559

[ Flash Point ]:
357.4±31.5 °C

[ Exact Mass ]:
505.210052

[ PSA ]:
97.69000

[ LogP ]:
3.10

[ Appearance of Characters ]:
colorless

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.634

[ Storage condition ]:
?20°C

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Inhibitors of Translation Targeting Eukaryotic Translation Initiation Factor 4A-Chapter Twenty

Meth. Enzymol. 511 , 437-61, (2012)

The RNA helicases eIF4AI and eIF4AII play key roles in recruiting ribosomes to mRNA templates during eukaryotic translation initiation. Small molecule inhibitors of eIF4AI and eIF4AII have been useful...

Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.

Cell Death Differ. 16(9) , 1289-99, (2009)

Drugs with tumor selectivity may have an important benefit in chemotherapies. We have previously shown that Rocaglamide(s), derived from the medicinal plant Aglaia, kills various leukemic cells throug...

Cyclorocaglamide, the first bridged cyclopentatetrahydrobenzofuran, and a related "open chain" rocaglamide derivative from Aglaia oligophylla.

J. Nat. Prod. 66(1) , 80-5, (2003)

Two rocaglamide-related natural products, the previously known compound 6-demethoxy-10-hydroxy-11-methoxy-6,7-methylendioxyrocaglamide (3), and cyclorocaglamide (4), its 8b,10-anhydro analogue, have b...


More Articles

Related Compounds

  • Rocaglamide J
  • Rocaglamide C
  • Rocaglamide I
  • Rocaglamide AL
  • (-)-rocaglamide
  • 4-ethoxy-1-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethoxy]acetyl}pyrrolidine-3-carboxylic acid
  • 1-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoyl]-4-methoxypyrrolidine-3-carboxylic acid
  • 1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoyl]-4-methoxypyrrolidine-3-carboxylic acid
  • 1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopropanecarbonyl]-4-methoxypyrrolidine-3-carboxylic acid
  • 1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanoyl]-4-methoxypyrrolidine-3-carboxylic acid
  • (S)-3,3-Dimethyl-2-(2,2,2-trifluoroacetamido)pent-4-ynoic acid
  • 4-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]-2,6-difluorobenzoic acid
  • 4-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-N-propylbutanamido]oxolane-3-carboxylic acid
  • 3-({1-[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]piperidin-4-yl}oxy)propanoic acid
  • 2-(2-{[(3S)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]methyl}-1,3-thiazol-4-yl)acetic acid
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