1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine

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Names

[ CAS No. ]:
84625-59-2

[ Name ]:
1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine

[Synonym ]:
DOTARIZINE
Dotarizinum
Dotarizina

Chemical & Physical Properties

[ Density]:
1.122 g/cm3

[ Boiling Point ]:
557.4ºC at 760 mmHg

[ Melting Point ]:
100-101ºC

[ Molecular Formula ]:
C29H34N2O2

[ Molecular Weight ]:
442.59200

[ Flash Point ]:
147.9ºC

[ Exact Mass ]:
442.26200

[ PSA ]:
24.94000

[ LogP ]:
4.94940

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL6610000
CHEMICAL NAME :
Piperazine, 1-(diphenylmethyl)-4-(3-(2-phenyl-1,3-dioxolan-2-yl)p ropyl)-
CAS REGISTRY NUMBER :
84625-59-2
LAST UPDATED :
199106
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C29-H34-N2-O2
MOLECULAR WEIGHT :
442.65

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1103,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1103,1987

Safety Information

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-(3-chloropropyl)-2-phenyl-1,3-dioxolane
  • N-Benzhydrylpiperazine
  • benzhydryl chloride

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Sodium ((2-(2-Methoxyethyl)-1,1-dioxido-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-6-yl)sulfonyl)amide
  • 2-(tert-butyl)-N-cyclopentyl-4-(4-(piperazin-1-yl)pyrimidin-2-yl)aniline
  • N-(Cyanomethyl)-N-ethyl-3-isoxazolecarboxamide
  • 4-[(3-Bromophenyl)sulfanyl]-3-fluorobenzonitrile
  • 4-[(3-Bromophenyl)sulfanyl]-2-chlorobenzonitrile
  • 5-(4-Methoxybenzyl)-1,2,4-thiadiazol-3-amine
  • 9H-Fluorene-2-carboxamide, N-[1-[(2,5-difluorophenyl)methyl]-4-methyl-1H-pyrazol-5-yl]-
  • 5-Bromo-2-[(1,3-dimethylbutyl)amino]-3-pyridinecarboxylic acid
  • 4-Thiazolemethanamine, I+/--methyl-2-(2-methyl-4-morpholinyl)-N-propyl-
  • 3-Cyclopropyl-4,5-dihydro-1,2-oxazole-5-carboxylic acid
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