Ritipenem

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Names

[ CAS No. ]:
84845-57-8

[ Name ]:
Ritipenem

[Synonym ]:
ritipenem acoxil

Chemical & Physical Properties

[ Density]:
1.71g/cm3

[ Boiling Point ]:
659.4ºC at 760 mmHg

[ Molecular Formula ]:
C10H12N2O6S

[ Molecular Weight ]:
288.27700

[ Flash Point ]:
352.6ºC

[ Exact Mass ]:
288.04200

[ PSA ]:
155.46000

[ Index of Refraction ]:
1.691

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI0191750
CHEMICAL NAME :
4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)- 6-(1-hydroxyethyl)-7-oxo-, (5R-(5alpha,6alpha(R*)))-
CAS REGISTRY NUMBER :
84845-57-8
LAST UPDATED :
199606
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H12-N2-O6-S
MOLECULAR WEIGHT :
288.30

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in potassium
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 29,3475,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3500 mg/kg/7D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in chlorine
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 29,3475,1995

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • RITIPENEM ACOXIL
  • Ritipenem sodium
  • 3-(4-Methoxyphenyl)-2,3-dimethylpiperidine
  • (R)-1-(5-Bromofuran-2-yl)pentan-1-amine
  • Methyl 5-(amino(cyclopropyl)methyl)nicotinate
  • Methyl 3-hydroxy-4-methoxy-1H-indole-2-carboxylate
  • 2-Bromo-4-chloro-6-fluorobenzotrifluoride
  • (R)-1-(4-Methoxy-3-methylphenyl)but-3-en-1-amine
  • 6,6'-Dibromo-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]
  • 3-Bromo-2-(piperidin-3-yl)imidazo[1,2-a]pyridine
  • 2-(4-Chloro-2-fluoro-6-iodophenyl)acetic acid
  • 2-(Trifluoromethyl)thiazolo[5,4-d]pyrimidine-7(6H)-thione
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