Foretinib (GSK1363089)

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Names

[ CAS No. ]:
849217-64-7

[ Name ]:
Foretinib (GSK1363089)

[Synonym ]:
4-(4-(o-Methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-1-butanol dihydrochloride
1-Butanol,4-(4-(o-methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-,dihydrochloride
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol dihydrochloride
1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-
EXEL-2880
4-(4-Hydroxy-4-(3,4,5-trimethoxyphenyl)butyl)-1-(o-methoxyphenyl)piperazine dihydrochloride
N-[3-fluoro-4-([6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl]oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Foretinib
N1-{3-fluoro-4-[(6-(methyloxy)-7-{[3-(4-morpholinyl)propyl]oxy}-4-quinolinyl)oxy]phenyl}-N1'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
N-[3-Fluoro-4-({6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl}oxy)phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
828.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C34H34F2N4O6

[ Molecular Weight ]:
632.654

[ Flash Point ]:
454.8±34.3 °C

[ Exact Mass ]:
632.244629

[ PSA ]:
116.45000

[ LogP ]:
5.12

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
  • N1'-[3-fluoro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
  • 4-(3-Chloropropyl)morpholine hydrochloride
  • N-(3-fluoro-4-hydroxyphenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

DownStream

Related Compounds

  • Foretinib H2O
  • SJF 8240
  • Androst-4-en-3-one, 17-[(hydroxymethylphosphinyl)oxy]-, (17beta)-
  • 2-[(4-Fluorophenyl)(methylsulfonyl)amino]-N-(1-methylbutyl)butanamide
  • 2-[(4-Fluorophenyl)(methylsulfonyl)amino]-N-[4-(1-pyrrolidinylsulfonyl)phenyl]butanamide
  • N-(4-Bromo-3-methylphenyl)-2-[(3,4-dimethylphenyl)(methylsulfonyl)amino]butanamide
  • N-[3-(Dimethylamino)propyl]-2-[(3,4-dimethylphenyl)(methylsulfonyl)amino]butanamide
  • 18-Oxooctadecanoic acid
  • (2Z)-2-cyano-N-[5-(4-methylbenzyl)-1,3-thiazol-2-yl]-3-{5-[3-(trifluoromethyl)phenyl]furan-2-yl}prop-2-enamide
  • 3-(5-(4-Chlorobenzyl)thiazol-2-yl)-2-imino-5-methylthiazolidin-4-one
  • 3-(5-(3-Chlorobenzyl)thiazol-2-yl)-2-imino-5-methylthiazolidin-4-one
  • 3-(5-(4-Ethylbenzyl)thiazol-2-yl)-2-imino-5-methylthiazolidin-4-one
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