Foretinib (GSK1363089)

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Names

[ CAS No. ]:
849217-64-7

[ Name ]:
Foretinib (GSK1363089)

[Synonym ]:
4-(4-(o-Methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-1-butanol dihydrochloride
1-Butanol,4-(4-(o-methoxyphenyl)piperazinyl)-1-(3,4,5-trimethoxyphenyl)-,dihydrochloride
4-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)butan-1-ol dihydrochloride
1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-
EXEL-2880
4-(4-Hydroxy-4-(3,4,5-trimethoxyphenyl)butyl)-1-(o-methoxyphenyl)piperazine dihydrochloride
N-[3-fluoro-4-([6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl]oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Foretinib
N1-{3-fluoro-4-[(6-(methyloxy)-7-{[3-(4-morpholinyl)propyl]oxy}-4-quinolinyl)oxy]phenyl}-N1'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
N-[3-Fluoro-4-({6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl}oxy)phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
828.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C34H34F2N4O6

[ Molecular Weight ]:
632.654

[ Flash Point ]:
454.8±34.3 °C

[ Exact Mass ]:
632.244629

[ PSA ]:
116.45000

[ LogP ]:
5.12

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
-20°C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
  • N1'-[3-fluoro-4-[(7-hydroxy-6-methoxy-4-quinolyl)oxy]phenyl]-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
  • 4-(3-Chloropropyl)morpholine hydrochloride
  • N-(3-fluoro-4-hydroxyphenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

DownStream

Related Compounds

  • Foretinib H2O
  • SJF 8240
  • 6-(4-chlorophenyl)-N-(2-methylpropyl)pyridazin-3-amine
  • 5-Bromo-3,4-dichlorobenzene-1,2-diamine
  • 1-[3-(propan-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-N-(1,3-thiazol-2-yl)piperidine-4-carboxamide
  • 1-{[1-(3-Methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]carbonyl}piperidine-4-carboxamide
  • 3-(4-Chlorobenzyl)-1,2-benzoxazol-6-yl morpholine-4-carboxylate
  • 3-(2-methylpropyl)-2-{4-[(propan-2-yloxy)acetyl]piperazin-1-yl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
  • 2-(6,7-dimethoxy-4-oxoquinazolin-3(4H)-yl)-N-(2-methoxybenzyl)acetamide
  • 1-methyl-N-{2-[(thiophen-2-ylsulfonyl)amino]ethyl}-1H-indole-2-carboxamide
  • 2-(Pyridin-3-yl)pyrimido[1,2-a]benzimidazole
  • 1-{[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetyl}piperidine-4-carboxylic acid
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