Cabozantinib (XL184, BMS-907351)

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Names

[ CAS No. ]:
849217-68-1

[ Name ]:
Cabozantinib (XL184, BMS-907351)

[Synonym ]:
N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
[14C]-Cabozantinib
Cometriq
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide
1,1-Cyclopropanedicarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-
XL 184
UNII-1C39JW444G
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Cabozantinib
BMS-907351
1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
XL-184
XL184

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
758.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H24FN3O5

[ Molecular Weight ]:
501.506

[ Flash Point ]:
412.3±32.9 °C

[ Exact Mass ]:
501.170013

[ PSA ]:
98.78000

[ LogP ]:
4.84

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.688

Safety Information

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Trifluoromethanesulfonic acid 6,7-dimethoxyquinolin-4-yl ester
  • N-(4-Fluorophenyl)-N'-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
  • 4-Fluoroaniline
  • Cyclopropane-1,1-dicarboxylic acid
  • 4-Hydroxy-6,7-dimethoxyquinoline
  • 4-Chloro-6,7-dimethoxyquinoline
  • 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
  • 4-Aminophenol

DownStream

  • Cabozantinib malate (XL184)

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Cabozantinib malate (XL184)
  • Cabozantinib-d4
  • Cabozantinib hydrochloride
  • N,N’-Bis(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
  • Cabozantinib impurity DYH
  • Cabozantinib Impurity 11
  • 2-{1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]-N-(2-methylpropyl)formamido}acetic acid
  • 3-(tert-Butoxy)-2-(3-(methoxymethyl)-5-methyl-4H-1,2,4-triazol-4-yl)propanoic acid
  • rac-1-[(3aR,7aS)-octahydro-1H-pyrrolo[2,3-c]pyridin-1-yl]-2,3,3-trimethylbutan-1-one
  • 3-(2,2-Dimethylpropyl)-5-formylthiophene-2-carboxylic acid
  • 5-Formyl-3-hexylthiophene-2-carboxylic acid
  • 3-(Cyclohexylmethyl)-5-formylthiophene-2-carboxylic acid
  • Ethyl 5-formyl-3-(pentan-3-yl)thiophene-2-carboxylate
  • 3-(Dichloro-1,3-thiazol-5-yl)-5-ethyl-1,2-oxazole-4-carboxylic acid
  • 5-Ethyl-3-(2-methyl-1,3-thiazol-4-yl)-1,2-oxazole-4-carboxylic acid
  • 1-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4,4-difluorobutanamido]methyl}cyclopropane-1-carboxylic acid
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