Phthalic anhydride

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Names

[ CAS No. ]:
85-44-9

[ Name ]:
Phthalic anhydride

[Synonym ]:
1,3-DIHYDRO-IMIDAZOL-2-ONE
4-imidazolin-2-one
MFCD00005918
1H-imidazol-2(3H)-one
phthallic anhydride
Phthalic anhydride
isobenzofuran-1,3-dione
1,3-dihydro-2H-imidazol-2-one
2-hydroxyimidazole
1,3-isobenzofurandione
2,3-dihydro-1H-imidazol-2-one
2,3-DIHYDRO-IMIDAZOL-2-ONE
EINECS 201-607-5
1,3-dihydroimidazolone
shellsd-8591
1,3-dihydroisobenzofuran-1,3-dione
2(3H)-Oxo-1H-imidazole
o-Phthalic acid anhydride
1,3-dihydro-2h-imidazol-2-on
2,3-Dihydroimidazole-2-one
sd8591

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
284 ºC

[ Melting Point ]:
129-132 ºC

[ Molecular Formula ]:
C₈H₄O₃

[ Molecular Weight ]:
148.116

[ Flash Point ]:
152 ºC

[ Exact Mass ]:
148.016037

[ PSA ]:
43.37000

[ LogP ]:
1.60

[ Vapour density ]:
5.1 (vs air)

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.613

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases, moisture, strong acids. Dust may form an explosive mixture with air.

[ Water Solubility ]:
6 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI3150000

CHEMICAL NAME :: Phthalic anhydride

CAS REGISTRY NUMBER :: 85-44-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 48

MOLECULAR FORMULA :: C8-H4-O3

MOLECULAR WEIGHT :: 148.12

WISWESSER LINE NOTATION :: T56 BVOVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1530 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >210 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/m3/2H/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Liver - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 6 gm/kg/42D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Gastrointestinal - gastritis Gastrointestinal - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1 mg/m3

SEX/DURATION :: male 45 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 203 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - rat Liver

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 6.1 mg/m3 (1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW BPCT** Progress Report from the Environmental Protection Agency to NIOSH on Benzenepolycarboxylates, 1974 Volume(issue)/page/year: -,183,1974 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,3,1973 TOXICOLOGY REVIEW CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- Volume(issue)/page/year: 10(3),49,1973 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 2 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,212,1971 OSHA PEL (Gen Indu):8H TWA 2 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 ppm (12 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (6.1 mg/m3) JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FINLAND:TWA 2 mg/m3;STEL 3 mg/m3;Skin JAN 1993 OEL-FRANCE:STEL 6 mg/m3 JAN 1993 OEL-GERMANY:TWA 5 mg/m3 JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-POLAND:TWA 1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 1 ppm (6 mg/m3);STEL 2 ppm (12 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.8 ppm (5 mg/m3);STEL 1.6 ppm (10 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (6 mg/m3);STEL 4 ppm (24 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHTHALIC ANHYDRIDE-air:10H TWA 1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 59230 No. of Facilities: 10056 (estimated) No. of Industries: 128 No. of Occupations: 90 No. of Employees: 134716 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 59230 No. of Facilities: 5265 (estimated) No. of Industries: 72 No. of Occupations: 67 No. of Employees: 81312 (estimated) No. of Female Employees: 14675 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H317-H318-H334-H335

[ Precautionary Statements ]:
P261-P280-P284-P304 + P340 + P312-P305 + P351 + P338 + P310-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R37/38;R41;R42/43

[ Safety Phrases ]:
S23-S24/25-S26-S37/39-S46-S22

[ RIDADR ]:
2214

[ WGK Germany ]:
1

[ RTECS ]:
TI3150000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2917350000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

o-xylene
Phthalane
Phthalic acid
diphenylisobenzofuran
N,N-Dimethylformamide
Phthaloyl chloride
1-Indanone
1H-Inden-1-one,2,2-dibromo-2,3-dihydro-
1,2-Dibromoindane

DownStream

2-(4-methoxyanilino)isoindole-1,3-dione
2-(4-fluoro-5,6,7,8-tetrahydronaphthalene-1-carbonyl)benzoic acid
3-[(3-methylphenyl)methylidene]-2-benzofuran-1-one
1H-Isoindole-1,3(2H)-dione,2,2'-(1,6-hexanediyl)bis-
2-[(4-fluoro-5,6,7,8-tetrahydronaphthalen-1-yl)methyl]benzoic acid
1H-Isoindole-1,3(2H)-dione,2,2'-(1,3-propanediyl)bis-
3-(3-fluoro-5,6,7,8-tetrahydronaphthalen-2-yl)-3-methyl-2-benzofuran-1-one
2-[4-(trichloromethyl)pyridin-2-yl]isoindole-1,3-dione
2-Ethyl-9,10-anthraquinone
2-(2-ethylbenzoyl)benzoic acid

Customs

[ HS Code ]: 2917350000

[ Summary ]:
HS:2917350000 isobenzofuran-1,3-dione VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB MFN tariff:6.5% General tariff:30.0%

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Phthalic anhydride-d4
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acetoxyphthalic anhydride
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Methyl5-(1-aminoethyl)-2-hydroxybenzoatehydrochloride
[3-(2,2,2-Trifluoroethyl)cyclohexyl]methanesulfonyl chloride
5-Isopropoxy-2-(tributylstannyl)pyrimidine
3-iodo-7-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyridine
(Cyclohexylmethyl)[(thiophen-3-yl)methyl]aminehydrochloride
methyl 2-(3-amino-N-methylpropanamido)acetate hydrochloride

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