afatinib

Suppliers

Names

[ CAS No. ]:
850140-72-6

[ Name ]:
afatinib

[Synonym ]:
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
(2E)-N-(4-[(3-chloro-4-fluorophenyl)amino]-7-{[(3S)-tetrahydrofuran-3-yl]oxy}quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Afatinib
Tovok
Tomtovok
(2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydro-3-furanyloxy]-6-quinazolinyl}-4-(dimethylamino)-2-butenamide
BIBW-2992
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Gilotrif

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
676.9±55.0 °C at 760 mmHg

[ Melting Point ]:
100 - 102 °C

[ Molecular Formula ]:
C24H25ClFN5O3

[ Molecular Weight ]:
485.938

[ Flash Point ]:
363.2±31.5 °C

[ Exact Mass ]:
485.162994

[ PSA ]:
88.61000

[ LogP ]:
3.59

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.668

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-(Dimethylamino)acetaldehyde sulfite
  • (S)-DIETHYL 2-(4-(3-CHLORO-4-FLUOROPHENYLAMINO)-7-(TETRAHYDROFURAN-3-YLOXY)QUINAZOLIN-6-YLAMINO)-2-OXOETHYLPHOSPHONATE
  • (2,2-diethoxyethyl)dimethylamine

DownStream

Related Compounds

  • Afatinib
  • R-Afatinib
  • Afatinib-d6
  • Afatinib maleate
  • Afatinib oxalate
  • (2Z)-Afatinib
  • (2S)-2-[2-(cyclopentylmethyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]butanoic acid
  • rac-3-{[(1R,2R)-2-ethylcyclopropyl]carbamoyl}-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
  • [1-(4-methoxybutyl)-5-(propan-2-yl)-1H-1,2,3-triazol-4-yl]methanol
  • [5-cyclopropyl-1-(pentan-3-yl)-1H-1,2,3-triazol-4-yl]methanol
  • [5-cyclopropyl-1-(1-cyclopropylethyl)-1H-1,2,3-triazol-4-yl]methanol
  • 3-(3-Bromophenyl)-4-hydroxy-1-oxa-7-azaspiro[4.4]non-3-en-2-one
  • [1-cyclopropyl-5-(cyclopropylmethyl)-1H-1,2,3-triazol-4-yl]methanol
  • [5-(cyclopropylmethyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-1,2,3-triazol-4-yl]methanol
  • [5-(2-methoxyethyl)-1-(3-methylbutan-2-yl)-1H-1,2,3-triazol-4-yl]methanol
  • [5-(1-methoxyethyl)-1-(3-methoxypropyl)-1H-1,2,3-triazol-4-yl]methanol
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