afatinib

Suppliers

Names

[ CAS No. ]:
850140-72-6

[ Name ]:
afatinib

[Synonym ]:
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-
(2E)-N-(4-[(3-chloro-4-fluorophenyl)amino]-7-{[(3S)-tetrahydrofuran-3-yl]oxy}quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Afatinib
Tovok
Tomtovok
(2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydro-3-furanyloxy]-6-quinazolinyl}-4-(dimethylamino)-2-butenamide
BIBW-2992
(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
Gilotrif

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
676.9±55.0 °C at 760 mmHg

[ Melting Point ]:
100 - 102 °C

[ Molecular Formula ]:
C24H25ClFN5O3

[ Molecular Weight ]:
485.938

[ Flash Point ]:
363.2±31.5 °C

[ Exact Mass ]:
485.162994

[ PSA ]:
88.61000

[ LogP ]:
3.59

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.668

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-(Dimethylamino)acetaldehyde sulfite
  • (S)-DIETHYL 2-(4-(3-CHLORO-4-FLUOROPHENYLAMINO)-7-(TETRAHYDROFURAN-3-YLOXY)QUINAZOLIN-6-YLAMINO)-2-OXOETHYLPHOSPHONATE
  • (2,2-diethoxyethyl)dimethylamine

DownStream

Related Compounds

  • Afatinib
  • R-Afatinib
  • Afatinib-d6
  • Afatinib maleate
  • Afatinib oxalate
  • (2Z)-Afatinib
  • 3-(1-Azetidinyl)-6-methylpyridazine
  • 2,6-Dichloro-3,5-dinitro-benzotrifluoride
  • 7-Chloroimidazo[1,5-a]pyridine-3-acetic acid
  • 2-(4-Bromo-3,5-dimethylphenyl)acetic acid
  • 1-(5-bromopyridin-3-yl)-N,N-dimethylethanamine
  • 5-cyclopropyl-5,6-dihydro-4H-thieno[2,3-c]pyrrole-2-carboxylic acid
  • 2-(2-Chloro-3-oxobutyl)benzeneacetic acid
  • 3-[(3-Bromo-5-fluorophenyl)methyl]pyrrolidine
  • 3-Methyl-3-(pentan-3-yloxy)azetidine
  • 5-(1-Chloroethyl)-3-(4-ethoxyphenyl)-4,5-dihydro-1,2-oxazole
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