2,6-Difluorobenzyl bromide

Names

[ Name ]:
2,6-Difluorobenzyl bromide

[Synonym ]:
2-(Bromomethyl)-1,3-difluorobenzene
MFCD00000329
FR CF B1E
2,6-Difluorobenzyl bromide
EINECS 285-652-6
α-Bromo-2,6-difluorotoluene
Benzene, 2-(bromomethyl)-1,3-difluoro-

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
184.9±25.0 °C at 760 mmHg

[ Melting Point ]:
52-55 °C(lit.)

[ Molecular Formula ]:
C₇H₅BrF₂

[ Molecular Weight ]:
207.015

[ Flash Point ]:
65.6±23.2 °C

[ Exact Mass ]:
205.954269

[ LogP ]:
3.06

[ Vapour Pressure ]:
1.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.523

MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S25

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,6-Difluorobenzyl alcohol
2,6-Difluorotoluene
2,6-Difluorobenzaldehyde

DownStream

2,6-Difluorophenylalanine
2,6-Difluorobenzoic acid
2-acetamido-3-(2,6-difluorophenyl)propanoic acid
N-Acetyl-2,6-difluoro-D-phenylalanine
2-(2,6-Difluorophenyl)acetonitrile
3-[(2S)-2-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro -3-methoxyphenyl)-2,4(1H,3H)-pyrimidinedione
2-(2,6-DIFLUOROPHENYL)-1H-1,3-BENZODIAZOLE
2-(benzenesulfonylmethyl)-1,3-difluorobenzene
Benzene, 1,3-difluoro-2-(fluoromethyl)- (9CI)
diethyl 2-[(2,6-difluorophenyl)methyl]propanedioate

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.

Bioorg. Med. Chem. Lett. 16(20) , 5345-9, (2006)

A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC...

A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists.

Bioorg. Med. Chem. Lett. 15(3) , 693-8, (2005)

A convenient one-pot synthetic route was developed for the preparation of asymmetric 1,3-dialkyl-1,3,5-triazine-2,4,6-triones from readily available alkyl- or aryl-isocyanates, primary amines and N-ch...

Efficient solid-phase synthesis of quinazoline-2-thioxo-4-ones with SynPhase™ lanterns. Makino S, et al.

Tetrahedron Lett. 41(43) , 8333-37, (2000)

4-Bromo-2,6-difluorobenzyl bromide
4-ethoxy-2,6-difluorobenzyl bromide
3-chloro-2,6-difluorobenzyl bromide
4-Chloro-2,6-difluorobenzyl bromide
(2,6-Difluorobenzyl)hydrazine hydrochloride
2,6-DIFLUOROBENZYL MERCAPTAN
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine